Stereoselective synthesis of pyrrolidines: Catalytic oxidative cyclizations mediated by osmium
Stereoselective synthesis of pyrrolidines: Catalytic oxidative cyclizations mediated by osmium
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DOI：
10.1002/anie.200603240
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Glossop, Paul A.
中科院分区：
文献类型：
--
作者：
Donohoe, Timothy J.;Churchill, Gwydion H.;Glossop, Paul A.
(Chemical Equation Presented) A new pathway for oxidative cyclization : N-protected α-amino alcohols with distal alkene units cyclize with complete stereoselectivity and stereospecificity to cispyrrolidines, dependent on the substitution pattern of the starting material. In addition to providing nitrogen- and oxygen-containing heterocycles in good to excellent yields, the catalyst loadings can be reduced to just 0.2 mol% osmium. TMO = Me 3NO, TFA = trifluoroacetic acid, Ts = toluene-4-sulfonyl. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.
