Neuronal death in the developing sexually dimorphic periventricular nucleus of the preoptic area in the female rat: Effect of neonatal androgen treatment
Neuronal death in the developing sexually dimorphic periventricular nucleus of the preoptic area in the female rat: Effect of neonatal androgen treatment
复制标题
雌性大鼠视前区发育中的性二形性室周核中的神经元死亡：新生雄激素治疗的效果
DOI：
10.1016/0304-3940(89)90076-1
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发表时间：
1989
影响因子：
2.5
通讯作者：
Y. Arai
中科院分区：
文献类型：
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作者：
S. Murakami;Y. Arai
用雄激素对雌性大鼠进行新生儿治疗会降低视前区前腹侧室周核（AVPv-POA）的核体积。为了检查雄激素对发育中的AVPv-POA中的神经底物的影响，该AVPv-POA在核体积中表现出性别二态性，比较了正常雌性和雄激素化雌性之间AVPv-POA中的细胞死亡模式。 Wistar雌性大鼠从出生之日起接受50μg丙酸睾酮（TP）治疗5天。从生命第 1 天到第 13 天，每三个切片对退化细胞（固缩细胞）和正常细胞进行计数。 TP处理的雌性在第7天和第10天处死时，细胞密度相对于1000个细胞的比率显着高于正常雌性。这些结果可能表明新生儿雄激素调节 AVPv-POA 中的神经元死亡，减少细胞核中的神经元数量。
Neonatal treatment of female rats with androgen decreases the nuclear volume of the anteroventral periventricular nucleus of the preoptic area (AVPv-POA). In order to examine the effect of androgen on the neural substrates in the developing AVPv-POA which show a sexual dimorphism in nuclear volume, the cell death pattern in the AVPv-POA was compared between normal females and androgenized females. Wistar female rats were treated with 50 μg of testosterone propionate (TP) for 5 days from the day of birth. Degenerating cells (pycnotic cells) and normal cells were counted in every third section from days 1 to 13 of life. The rate of pycnotic cells to 1000 cells in TP-treated females sacrificed at days 7 and 10 was significantly higher than that in normal females. These results may suggest that neonatal androgen regulates neuronal death in the AVPv-POA, decreasing the number of neurons in the nucleus.
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