DTI and VBM reveal white matter changes without associated gray matter changes in patients with idiopathic restless legs syndrome.
DTI and VBM reveal white matter changes without associated gray matter changes in patients with idiopathic restless legs syndrome.
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DOI：
10.1002/brb3.327
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发表时间：
2015-09
影响因子：
3.1
通讯作者：
Menzler K
中科院分区：
文献类型：
--
作者：
Belke M;Heverhagen JT;Keil B;Rosenow F;Oertel WH;Stiasny-Kolster K;Knake S;Menzler K
我们评估了虹膜白血病患者的大脑白质和灰质的变化，以阐明这种疾病的病理生理学。采用全头部弥散张量成像(DTI)和体素形态测量(VBM)技术，对12例虹膜虹膜瘤患者和12例年龄、性别匹配的对照组进行了比较。DTI扫描的评价包括各向异性分数(FA)、径向弥散系数(RD)和轴向弥散系数(AD)的体素分析。弥散张量成像显示双侧皮质下白质中FA改变的区域，主要位于颞区以及右侧内囊、桥脑和右侧小脑。这些变化与RD的变化重叠。基于体素的形态测量没有发现任何灰质变化。我们发现虹膜虹膜患者几个白质区域的弥散特性发生了改变。白质的变化主要归因于RD的变化，这是一个被认为反映髓鞘变化的参数。白质微结构改变的区域包括内囊中包括皮质脊髓束到下肢的区域，从而支持了与RLS相关的感觉运动通路改变的研究。
We evaluated cerebral white and gray matter changes in patients with iRLS in order to shed light on the pathophysiology of this disease. Twelve patients with iRLS were compared to 12 age- and sex-matched controls using whole-head diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) techniques. Evaluation of the DTI scans included the voxelwise analysis of the fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). Diffusion tensor imaging revealed areas of altered FA in subcortical white matter bilaterally, mainly in temporal regions as well as in the right internal capsule, the pons, and the right cerebellum. These changes overlapped with changes in RD. Voxel-based morphometry did not reveal any gray matter alterations. We showed altered diffusion properties in several white matter regions in patients with iRLS. White matter changes could mainly be attributed to changes in RD, a parameter thought to reflect altered myelination. Areas with altered white matter microstructure included areas in the internal capsule which include the corticospinal tract to the lower limbs, thereby supporting studies that suggest changes in sensorimotor pathways associated with RLS.