Comparison of bone morphogenetic protein receptors expression in the fetal and adult skin
Comparison of bone morphogenetic protein receptors expression in the fetal and adult skin
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DOI：
10.3349/ymj.2001.42.6.581
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发表时间：
2001-12-01
影响因子：
2.4
通讯作者：
Tark, KC
中科院分区：
文献类型：
--
作者：
Hwang, EA;Lee, HB;Tark, KC
胎儿皮肤上的伤口可以修复而不会留下疤痕，直到第二个三个月，但在此期间之后，皮肤伤口会像成人一样留下疤痕。已知某些生长因子如TGF-β和bFGF在胎儿皮肤的伤口修复过程中以非常低的水平存在。这些低水平的生长因子使伤口部位的炎症反应和成纤维细胞增殖最小化，这反过来又抑制胶原蛋白合成，从而允许无瘢痕伤口愈合。骨形态发生蛋白（BMPs）是TGF-β超家族成员之一，近年来在创伤愈合过程中的作用得到了研究。本研究采用免疫组化和RT-PCR方法，观察了BMP受体在孕中期胎儿皮肤和成人皮肤中的表达情况。BMP受体在成人皮肤的基底上上皮细胞和毛囊中检测到，但在胎儿皮肤中除了毛囊外没有缺陷。通过RT-PCR证实成人和胎儿皮肤中BMP受体的mRNA水平证实了这一点。总之，BMP和BMP受体似乎与胎儿和成人伤口愈合有关，在第二个三个月期间，BMP和BMP受体的低水平似乎有助于胎儿的无瘢痕伤口愈合，就像在第二个三个月期间的TGF-β一样。
Wounds on fetal skin can be repaired without leaving scars until the second trimester, but after thus period, skin wounds leave scars as in adults. It's known that certain growth factors such as TGF-beta, and bFGF are present at a very low levels during wound repair in fetal skin. These low levels of growth factors minimize inflammatory response and fibroblast proliferation at the wound site, which in turn inhibit collagen synthesis, and thus, allows scarless wound healing. Recently bone morphogenetic proteins (BMPs), one of the TGF-beta superfamily members, have been studied in the wound healing process. According to several studies, BMPs are related to the differentiation and growth of epithelial and mesenchymal cells, but the precise functions of BMPs and of BMP receptors on skin wound healing have not been elucidated.In thus study, we investigated the expression pattern of BMP receptors in fetal skin during the second trimester and in adult skin by immunohistochemical staining and RT-PCR. BMP receptors were detected on the suprabasal epithelial cells and in the hair follicles in adult skin, but were not defected in the fetal skin except for the hair follicles. This was confirmed by confirming mRNA levels of BMP receptors by RT-PCR in both adult and fetal skins.In conclusion, BMPs and BMP receptors seem to be related to fetal and adult wound healing, and low levels of BMPs and BMP receptors during the second trimester seem to contribute to scarless wound healing in the fetus, as is TGF-beta during the second trimester.