CHRONIC NEONATAL MK-801 TREATMENT RESULTS IN AN IMPAIRMENT OF SPATIAL-LEARNING IN THE ADULT-RAT
CHRONIC NEONATAL MK-801 TREATMENT RESULTS IN AN IMPAIRMENT OF SPATIAL-LEARNING IN THE ADULT-RAT
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DOI：
10.1016/0006-8993(92)90921-u
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发表时间：
1992-05-15
期刊：
影响因子：
2.9
通讯作者：
DEBRUIN, JPC
中科院分区：
文献类型：
--
作者：
GORTER, JA;DEBRUIN, JPC
从出生后第8天到第19天，用非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801对新生儿进行慢性治疗，已显示会影响成年大鼠的海马NMDA受体功能10。由于许多研究表明NMDA受体在学习和记忆中起着至关重要的作用，并且由于海马的功能之一是空间学习，因此我们研究了海马神经元的这种变化的反应是否与其正常功能的变化有关。因此，我们在MK-801给药的成年大鼠中使用水迷宫测试了空间学习和记忆。MK-801处理的大鼠能够像对照大鼠一样学习空间任务，但速度明显较慢。在视觉提示任务的性能不受新生儿治疗，这表明较慢的空间学习不是由运动或感觉缺陷。这些结果表明，慢性NMDA受体阻滞剂在新生儿期导致海马功能的长期干扰。
Chronic neonatal treatment with the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 from postnatal day 8 through 19 has been shown to affect hippocampal NMDA receptor function of adult rats10. Since many studies have shown that NMDA receptors play a crucial role in learning and memory, and since one of the hippocampal functions is spatial learning, we have examined whether this changed response of hippocampal neurons is associated with changes in its normal function. We therefore tested spatial learning and memory using a water maze in adult rats neonatally treated with MK-801. MK-801-treated rats were able to learn the spatial task as well as control rats but at a significantly slower rate. Performance in a visual cue task was not affected by the neonatal treatment, suggesting that the slower spatial learning is not caused by locomotor or sensory deficits. These results suggest that chronic NMDA receptor blockade during the neonatal period leads to long-lasting disturbances of hippocampal function.