Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility
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基于介孔二氧化硅纳米颗粒的纳米药物递送系统：合成、控制药物释放和递送、药代动力学和生物相容性
DOI：
10.1039/c0jm03851b
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发表时间：
2011-01-01
影响因子：
--
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
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作者：
He, Qianjun;Shi, Jianlin
介孔二氧化硅纳米粒子作为高效药物载体的生物医学应用在过去十年中引起了极大的关注。已经发现MSNs的结构、形态、尺寸和表面性质对于药物装载、控制药物释放和递送以及多功能化的目的是容易可调的。与此同时，基于MSN的纳米给药系统（Nano-DDS）的生物安全性和体内药效，包括生物相容性（包括细胞毒性、血液和组织相容性）和药代动力学（包括生物分布、生物降解、滞留、排泄、血液循环），也因其临床应用前景而受到越来越多的关注。本文综述了近年来MSNs在合成、药物控释、药代动力学和生物相容性等方面的研究进展。
The biomedical applications of mesoporous silica nanoparticles (MSNs) as efficient drug delivery carriers have attracted great attention in the last decade. The structure, morphology, size, and surface properties of MSNs have been found to be facilely tunable for the purposes of drug loading, controlled drug release and delivery, and multifuctionalization. Meanwhile, the biosafety and in vivo drug efficiency of MSN-based nano drug delivery systems (nano-DDSs), involving biocompatibility (including cytotoxicity, blood and tissue compatibility) and pharmacokinetics (including biodistribution, biodegradation, retention, excretion, blood circulation) are also drawing increasing attention because of their clinical application prospects. Herein, we review the most recent research progresses on the synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility of MSNs.