Functional relationship between adrenal medullary and cortical hormones in man.
Functional relationship between adrenal medullary and cortical hormones in man.
复制标题
人肾上腺髓质和皮质激素之间的功能关系。
DOI：
10.1093/oxfordjournals.qjmed.a066947
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发表时间：
1961
期刊：
影响因子：
--
通讯作者：
E. Ross
中科院分区：
文献类型：
--
作者：
E. Ross
DESPITE the anatomical contiguity of the cortex and the medulla of the adrenal gland, the functional relationship between the two parts of the gland in man has been insufficiently defined. Animal experiments have implied that the two embryologically dissimilar tissues may be functionally closely related. The dog, for example, has been found after adrenalectomy to be less sensitive to the pressor effect of infused noradrenaline (Ramey, Goldstein, and Levine, 1951) or adrenaline (Cleghorn, Fowler, Greenwood, and Clarke, 1950) than the intact animal. The pressor response of human normotensive subjects to noradrenaline has been shown to be increased by pre-treatment with deoxycorticosterone (Raab, 1942), and to be decreased in patients with adrenal insufficiency (am Ende, 1939). These and other observations have suggested that a functional relationship between the two parts of the adrenal gland may exist in man. Observations on a patient with a phaeochromocytoma, in whom adrenal insufficiency supervened, have confirmed the suspicion of such relationship. Additional experimental data are presented which throw further light on its mechanism.
