Pharmacokinetics of tramadol and o-desmethyltramadol in goats after intravenous and oral administration.
Pharmacokinetics of tramadol and o-desmethyltramadol in goats after intravenous and oral administration.
复制标题
DOI：
10.1111/j.1365-2885.2007.00916.x
复制
发表时间：
2007-11
影响因子：
1.3
通讯作者：
A. B. D. Sousa;Andréa Carla Brandão da Costa Santos;S. Schramm;V. Porta;S. L. Górniak;Jorge Camilo Flório;H. S. Spinosa
中科院分区：
文献类型：
--
作者：
A. B. D. Sousa;Andréa Carla Brandão da Costa Santos;S. Schramm;V. Porta;S. L. Górniak;Jorge Camilo Flório;H. S. Spinosa
本试验的目的是实施一种方法，以获得用于分析山羊血浆中曲马多及其主要代谢产物o-去甲基曲马多（M1）的工具，并评价这些物质在静脉内（i. v.）和口服（p.o.）给雌性山羊服用。在i. v.或p.o.后检查曲马多和M1的药代动力学。向6只雌性山羊施用曲马多（2 mg/kg）。曲马多和M1的平均保留时间分别为5.13 min和2.42 min。静脉给予2 mg/kg盐酸曲马多后，半衰期、分布容积和全身清除率的计算参数分别为0.94+/-0.34 h、2.48+/-0.58 L/kg和2.18+/-0.23 L/kg/h。曲马多2 mg/kg p.o.给药后，全身利用度为36.9+/-9.1%，半衰期为2.67+/-0.54 h。曲马多静脉给药后，M1的半衰期为2.89+/-0.43 h。在邮政局之后，未检测到M1。
The aim of this trial was to implement a method to obtain a tool for analyses of tramadol and the main metabolite, o-desmethyltramadol (M1), in goat's plasma, and to evaluate the pharmacokinetics of these substances following intravenous (i.v.) and oral (p.o.) administration in female goats. The pharmacokinetics of tramadol and M1 were examined following i.v. or p.o. tramadol administration to six female goats (2 mg/kg). Average retention time was 5.13 min for tramadol and 2.42 min for M1. The calculated parameters for half-life, volume of distribution and total body clearance were 0.94+/-0.34 h, 2.48+/-0.58 L/kg and 2.18+/-0.23 L/kg/h following 2 mg/kg tramadol HCl administered intravenously. The systemic availability was 36.9+/-9.1% and half-life 2.67+/-0.54 h following tramadol 2 mg/kg p.o. M1 had a half-life of 2.89+/-0.43 h following i.v. administration of tramadol. Following p.o., M1 was not detectable.