RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
RNF43 Inhibits Cancer Cell Proliferation and Could be a Potential Prognostic Factor for Human Gastric Carcinoma
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DOI：
10.1159/000430154
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发表时间：
2015-01-01
影响因子：
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通讯作者：
Chen, Lin
中科院分区：
文献类型：
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作者：
Niu, Lei;Qin, Hong-Zhen;Chen, Lin
背景/目的：RNF 43是跨膜E3泛素连接酶的成员，在肿瘤的形成和发展中起重要作用。本研究旨在探讨RNF 43在胃癌中的表达及其意义。方法和结果：采用实时PCR、蛋白质印迹和免疫组化方法检测77例胃癌组织和相应正常组织中RNF 43的水平。我们发现RNF 43在胃癌组织中的表达明显低于正常胃粘膜（P
Background/Aims: RNF43 is a member of transmembrane E3 ubiquitin ligases and plays important roles in tumor formation progression. In current study, we aimed to explore RNF43 expression and analyze its role in gastric carcinoma. Methods and Results: The level of RNF43 was detected in 77 cases of gastric carcinoma and matched normal tissues by real-time PCR, western blotting and immunohistochemistry. We found that the expression of RNF43 was significantly down-regulated in the gastric carcinoma tissues compared to the normal mucosae (all P