Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections.
Potential therapeutic targets from Mycobacterium abscessus (Mab): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections.
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来自分枝杆菌（Mab）的潜在治疗靶点：最近报道了发现新型抗菌剂治疗Mab感染的努力。
DOI：
10.1039/d1md00359c
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发表时间：
2022-04-20
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
脓肿分枝杆菌(Mab)是一种生长迅速的分枝杆菌，可在皮肤和肺组织中引起严重和持续的感染。治疗方案涉及延长复杂药物组合的使用，往往会导致严重的副作用，特别是在免疫功能低下的患者中。目前的大环内酯疗法逐渐被证明是不那么有效的，这主要是由于抗生素耐药性的出现；因此，越来越需要发现对单抗有效的新的抗菌药。本文重点介绍了单抗的一些潜在治疗靶点(Ag85C、ClpC1、GyrB、MmpL3和TrmD)的最新研究，并讨论了用于发现小分子抑制剂的各种方法，以寻找未来治疗单抗感染的抗生素。最近报道了针对absecessus分枝杆菌(Mab)靶标的抑制剂。
Mycobacterium abscessus (Mab) are rapidly growing mycobacteria that cause severe and persistent infections in both skin and lung tissues. Treatment regimens involve the extended usage of complex combinations of drugs, often leading to severe adverse side effects, particularly in immunocompromised patients. Current macrolide therapies are gradually proving to be less effective, largely due to emergence of antibiotic resistance; there is therefore an increasing need for the discovery of new antibacterials that are active against Mab. This review highlights recent research centred upon a number of potential therapeutic targets from Mab (Ag85C, ClpC1, GyrB, MmpL3 and TrmD), and discusses the various approaches used to discover small molecule inhibitors, in the search for future antibiotics for the treatment of Mab infections. Recently reported inhibitors developed against targets from Mycobacterium absecessus (Mab).
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