Development and functions of the choroid plexus-cerebrospinal fluid system.
Development and functions of the choroid plexus-cerebrospinal fluid system.
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DOI：
10.1038/nrn3921
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Lehtinen MK
中科院分区：
文献类型：
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作者：
Lun MP;Monuki ES;Lehtinen MK
脉络膜丛（ChP）是脑脊液（CSF）的主要来源，已被公认为脊椎动物神经系统废物的液垫和汇。各种动物模型提供了对ChP-CSF系统如何发展和成熟的见解。此外，最近的研究发现，这一动态系统在神经干细胞、关键时期和神经系统整体健康的调节中发挥了新的积极作用。总之，这些发现使我们对大脑发育和健康的理解发生了范式转变，并激发了神经系统疾病治疗的新举措。
The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates. Various animal models have provided insight into how the ChP–CSF system develops and matures. In addition, recent studies have uncovered new, active roles for this dynamic system in the regulation of neural stem cells, critical periods and the overall health of the nervous system. Together, these findings have brought about a paradigm shift in our understanding of brain development and health, and have stimulated new initiatives for the treatment of neurological disease.