Association of the maternal serum albumin level with fetal growth and fetal growth restriction in term-born singletons: a prospective cohort study
Association of the maternal serum albumin level with fetal growth and fetal growth restriction in term-born singletons: a prospective cohort study
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足月出生的单胎母亲血清白蛋白水平与胎儿生长和胎儿生长受限的关系：一项前瞻性队列研究
DOI：
10.1016/j.fertnstert.2021.09.016
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发表时间：
2022-02-03
影响因子：
6.7
通讯作者：
Hao, Liping
中科院分区：
文献类型：
--
作者：
Xiong, Ting;Wu, Yuanjue;Hao, Liping
目的：探讨单胎足月儿中母体血清白蛋白 (MAlb) 水平与胎儿生长和胎儿生长受限 (FGR) 风险的关系。设计：前瞻性队列研究。地点：2013 年 9 月至 2016 年 4 月在中国中部武汉市启动的同济妇幼健康队列研究的四个医院妇产科。患者：总共 3,065 对母子。干预：无。 主要结果指标：通过出生体重 (BW) 和出生身长评估胎儿生长情况。胎儿生长受限定义为体重低于第 10 个百分位。结果：所有 MAlb 水平均在正常上限内。调整肝功能参数、炎症指标等后，观察到 MAlb 与胎儿生长之间呈倒 U 形关系。具体而言，当 MAlb 水平为 36.1 g/L 时，BW 随着 MAlb 水平的增加而显着增加（每 g/L：b = 36.8；95% CI，0.8，72.7），但当 MAlb 水平为 36.1 g/L 时，BW 随着 MAlb 水平的增加而减少（每 g/L：b = -15.1；95% CI，-21.2，-8.9）。 MAlb 与出生身长之间也存在类似的关联。此外，随着 MAlb 水平增加的三分位数，调整后的 FGR 奇数比为 1.0（参考）、1.1（0.7，1.8）和 1.7（1.0，2.6）。 结论：MAlb 与胎儿生长之间存在反向 U 形关联。 MAlb 水平较高与 FGR 风险增加相关。临床试验注册号：NCT03099837。 （Fertil Sterile 2022；117:368-75。(c) 2021 年，美国生殖医学会。）
Objective: To investigate the association of the maternal serum albumin (MAlb) level with fetal growth and fetal growth restriction (FGR) risk in term-born singletons.Design: Prospective cohort study.Setting: Four hospital maternity units of the Tongji Maternal and Child Health Cohort study initiated from September 2013 to April 2016 at Wuhan City, in central China.Patient(s): A total of 3,065 mother-offspring pairs.Intervention(s): None.Main Outcome Measure(s): Fetal growth was evaluated by birth weight (BW) and birth length. Fetal growth restriction was defined as BW below the 10th percentile.Result(s): All MAlb levels were within the upper limit of normal. After adjustment for liver function parameters, inflammatory indicators, and others, a reverse U-shaped relationship between MAlb and fetal growth was observed. Specifically, BW increased significantly with an increasing MAlb level when the MAlb level was 36.1 g/L (per g/L: b = 36.8; 95% CI, 0.8, 72.7) but decreased with increasing the MAlb level when the MAlb level was 36.1 g/L (per g/L: b = -15.1; 95% CI, -21.2, -8.9). There was a similar association between MAlb and birth length. Furthermore, the adjusted odd ratios of FGR across increasing tertiles of the MAlb levels were 1.0 (reference), 1.1 (0.7, 1.8), and 1.7 (1.0, 2.6).Conclusion(s): There was a reverse U-shaped association between MAlb and fetal growth. A higher MAlb level was associated with an increased risk of FGR. Clinical Trial Registration Number: NCT03099837. (Fertil Sterile 2022;117:368-75. (c) 2021 by American Society for Reproductive Medicine.)