Coating of vesicles with hydrophilic reactive polymers.
Coating of vesicles with hydrophilic reactive polymers.
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用亲水性反应性聚合物涂覆囊泡
DOI：
10.1021/la800119w
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
H. Schlaad
中科院分区：
文献类型：
--
作者：
C. Koňák;V. Šubr;L. Kostka;P. Štěpánek;K. Ulbrich;H. Schlaad
在表面上具有阳离子（氨基）基团或两性离子（氨基酸）基团的囊泡用反应性多价双N-（2-羟丙基）甲基丙烯酰胺聚合物（PHPMA）及其带正电荷的类似物（3摩尔%季铵基团）涂覆，这两种聚合物均具有反应性噻唑烷-2-酮（TT）基团，其沿聚合物链沿着随机分布。将囊泡以lmg/mL的浓度分散在水中。评价了模型囊泡的表面电荷对表面包被效率的影响。使用光散射方法测试模型囊泡的重均分子量、流体动力学尺寸和微重力势的变化。对于用带正电荷的亲水性PHPMA-TT共聚物涂覆的两性离子囊泡，在反应性聚合物的浓度cp = 2 mg/mL下观察到囊泡的最有效涂覆。包被效率是超过1个数量级高于获得的带正电荷的囊泡包被的不带电的亲水性聚合物在samecp。
Vesicles bearing either cationic (amino) groups or zwitterionic (amino acid) groups on the surface were coated with a reactive multivalent hydrophilicN-(2-hydroxypropyl)methacrylamide polymer (PHPMA) and its positively charged analogue (3 mol % quaternary ammonium groups), both having reactive thiazolidine-2-thione (TT) groups randomly distributed along the polymer chain. The vesicles were dispersed in water at a concentration of 1 mg/mL. The effect of surface charges of model vesicles on the surface coating efficiency was evaluated. The changes in the weight-average molecular weight, in the hydrodynamic size, and in the ζ-potential of model vesicles were tested using light scattering methods. The most effective coating of vesicles was observed for the zwitterionic vesicles coated with the positively charged hydrophilic PHPMA-TT copolymer at a concentration of reactive polymercp= 2 mg/mL. The coating efficiency was more than 1 order of magnitude higher than that obtained for positively charged vesicles coated by the uncharged hydrophilic polymer at the samecp.