The crosstalk between bacteria and host autophagy: host defense or bacteria offense
The crosstalk between bacteria and host autophagy: host defense or bacteria offense
复制标题
细菌与宿主自噬之间的串扰：宿主防御还是细菌进攻
DOI：
10.1007/s12275-022-2009-z
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发表时间：
2022
影响因子：
3
通讯作者：
Guolin Li
中科院分区：
文献类型：
--
作者：
Lin Zheng;Fang Wei;Guolin Li
异噬是一种特异性的选择性自噬，用于清除细胞内细菌。目前的证据表明，宿主自噬系统识别和清除入侵细菌的过程是复杂的，并且根据不同的病原体而有所不同。尽管宿主体内存在泛素依赖性和非泛素依赖性的自噬以防御入侵细菌，但成功的病原体已经进化出多种策略来逃避或瘫痪宿主的自噬系统。本文主要讨论了宿主自噬系统识别和清除胞内病原体的机制，以及不同病原体逃逸或瘫痪宿主自噬系统的机制，并重点介绍了研究最广泛的细菌。
Xenophagy is a specific selective autophagy for the elimination of intracellular bacteria. Current evidence suggests that the processes for host autophagy system to recognize and eliminate invading bacteria are complex, and vary according to different pathogens. Although both ubiquitin-dependent and ubiquitin-independent autophagy exist in host to defense invading bacteria, successful pathogens have evolved diverse strategies to escape from or paralyze host autophagy system. In this review, we discuss the mechanisms of host autophagy system to recognize and eliminate intracellular pathogens and the mechanisms of different pathogens to escape from or paralyze host autophagy system, with a particular focus on the most extensively studied bacteria.