The distribution, elimination, and in vivo biotransformation of aldicarb in the rainbow trout (Oncorhynchus mykiss).
The distribution, elimination, and in vivo biotransformation of aldicarb in the rainbow trout (Oncorhynchus mykiss).
复制标题
涕灭威在虹鳟鱼 (Oncorhynchus mykiss) 中的分布、消除和体内生物转化。
DOI：
10.1016/0272-0590(92)90205-v
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Buhler,DR
中科院分区：
文献类型：
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作者：
Schlenk,D;Erickson,DA;Lech,JJ;Buhler,DR
虹鳟（Oncorhynchus mykiss）中灭威的分布、消除及体内生物转化。施伦克，D.，埃里克森，D.，莱赫，J. J.，和布勒，D. R.（1992）。达成。Toxicol.18, 131 - 136。研究了虹鳟（Oncorhynchus mykiss）口服和腹腔注射[14C]灭威在虹鳟体内的分布和消除情况。对口服[14C]涕灭威的鳟鱼，在长达96小时的不同时间段内，通过监测放射性来测定组织残留物。对经腹腔注射[14C]灭威的自由游动鱼和脊椎横切鱼，在24小时后获得周期性水样和单一组织残留放射性水平。涕灭威似乎被迅速吸收（3小时内99%）并分布到所有组织。两种剂量组的消除谱均显示出快速的β期（口服24小时，口服3小时），可能是由于鳃裂排泄（注射ip后96%），随后是较慢的β期（口服107小时，口服28小时），提示有较深的隔室，如肌肉。[14C]阿灭威和/或其代谢物在24小时后缓慢转运至胆汁。[14C]灭威在脊髓横切的鳟鱼中注射24小时后的体内转化情况。发现的主要代谢物是灭威亚砜（7.6%）和少量灭威肟（5.4%）。
The Distribution, Elimination, andin VivoBiotransformation of Aldicarb in the Rainbow Trout (Oncorhynchus mykiss). SCHLENK, D., ERICKSON, D. A., LECH, J. J., AND BUHLER, D. R. (1992).Fundam. Appl. Toxicol.18, 131–136.The distribution and elimination of[14C]aldicarb, administered orally and by intraperitoneal (ip) injection, was examined in the rainbow trout (Oncorhynchus mykiss). Tissue residues were determined by monitoring radioactivity at various time periods up to 96 hr in trout administered [14C]aldicarb orally. Periodic water samples and a single tissue residue radioactivity level were obtained after 24 hr in free swimming and spinally transected fish which received [14C]aldicarb via intraperitoneal injection. Aldicarb appears to be absorbed rapidly (99% within 3 hr) and distributed to all tissues. Elimination profiles from both dosage groups demonstrate a rapid a phase (oral 24 hr; ip 3 hr) probably due to branchial excretion (96% after ip injection) followed by a slowerβphase (oral 107 hr; ip 28 hr) suggesting a deeper compartment such as muscle. [14C]Aldicarb and/or its metabolites were slowly being transported to the bile after 24 hr. Thein vivobiotransformation of [14C]aldicarb was examined in spinally transected trout 24 hr after ip injection. The major metabolite found was aldicarb sulfoxide (7.6%) along with lesser amounts of aldicarb oxime (5.4%).