Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord
Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord
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DOI：
10.1136/jnnp.2008.148767
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发表时间：
2009-02-01
影响因子：
11
通讯作者：
Evangelou, N.
中科院分区：
文献类型：
--
作者：
Gilmore, C. P.;Donaldson, I.;Evangelou, N.
背景：在多发性硬化症(MS)中，大脑皮质和脊髓都会出现实质性灰质(GM)脱髓鞘。GM脱髓鞘也发生在小脑皮层和大脑深层GM核。目的：研究MS患者运动皮质、扣带回、小脑、丘脑和脊髓中GM脱髓鞘的程度和模式。方法：对14例MS患者和3例对照进行尸检。取五个预定区域的切片，进行蛋白脂蛋白染色。结果和结论：总体而言，28.8%的GM脱髓鞘，而WM的脱髓鞘比例为15.6%(p<；0.001)，在每个解剖部位，GM的脱髓鞘程度大于WM。不同中枢神经系统区域的脱髓鞘程度有很大差异。GM脱髓鞘最广泛见于脊髓和小脑，而西医脱髓鞘最明显见于脊髓。
Background: Substantial grey matter (GM) demyelination occurs in both the cerebral cortex and spinal cord in multiple sclerosis (MS). GM demyelination also occurs in the cerebellar cortex and the deep GM nuclei of the brain. However, no study has made a direct "within subject" comparison of the extent of GM pathology between these regions.Aim: To examine the extent and pattern of GM demyelination in the motor cortex, cingulate gyrus, cerebellum, thalamus and spinal cord in MS.Methods: Postmortem study using material from 14 MS cases and three controls. Sections were taken from the five predetermined areas and stained for proteolipid protein. The extent of GM and white matter (WM) demyelination was assessed in each region.Results and conclusion: Overall, 28.8% of the GM was demyelinated compared with 15.6% of the WM (p < 0.001), with demyelination being greater in the GM than in the WM at each of the anatomical sites. There was substantial variation in the extent of demyelination between the different CNS regions. GM demyelination was most extensive in the spinal cord and cerebellum while WM demyelination was most prominent in the spinal cord.