Development of anatomically realistic numerical breast phantoms with accurate dielectric properties for modeling microwave interactions with the human breast.
Development of anatomically realistic numerical breast phantoms with accurate dielectric properties for modeling microwave interactions with the human breast.
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DOI：
10.1109/tbme.2008.2002130
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发表时间：
2008-12
影响因子：
4.6
通讯作者：
Hagness, Susan C.
中科院分区：
文献类型：
--
作者：
Zastrow, Earl;Davis, Shakti K.;Lazebnik, Mariya;Kelcz, Frederick;Van Veen, Barry D.;Hagness, Susan C.
关键词：
微波与人类乳房相互作用的计算电磁学模型是探索新技术可行性和改进微波乳腺癌检测和治疗相关设计概念的宝贵工具。在本文中，我们报告了一个收集的解剖学上逼真的三维数值乳房幻影的不同形状，大小和射线密度，可以很容易地用于FDTD计算电磁模型的发展。体模来自俯卧位患者的T1加权磁共振图像（MRI）。使用几个步骤将每个MRI转换为介电特性的均匀网格。首先，通过将图像处理技术应用于MRI来识别每个体模的结构。接下来，通过分段线性映射将MRI的体素强度转换为正常乳腺组织的频率依赖性和组织依赖性介电特性。正常乳腺组织的介电特性取自最近完成的由威斯康星州和卡尔加里大学进行的正常乳腺组织介电特性的大规模实验研究。科学界可通过一个在线储存库获得数字幻影的全面收集。
Computational electromagnetics models of microwave interactions with the human breast serve as an invaluable tool for exploring the feasibility of new technologies and improving design concepts related to microwave breast cancer detection and treatment. In this paper we report the development of a collection of anatomically realistic 3D numerical breast phantoms of varying shape, size, and radiographic density which can be readily used in FDTD computational electromagnetics models. The phantoms are derived from T1-weighted magnetic resonance images (MRIs) of prone patients. Each MRI is transformed into a uniform grid of dielectric properties using several steps. First, the structure of each phantom is identified by applying image processing techniques to the MRI. Next, the voxel intensities of the MRI are converted to frequency-dependent and tissue-dependent dielectric properties of normal breast tissues via a piecewise-linear map. The dielectric properties of normal breast tissue are taken from the recently completed large-scale experimental study of normal breast tissue dielectric properties conducted by the Universities of Wisconsin and Calgary. The comprehensive collection of numerical phantoms is made available to the scientific community through an online repository.