Convergent synthesis of oligomers of triazole-linked DNA analogue (TLDNA) in solution phase
Convergent synthesis of oligomers of triazole-linked DNA analogue (TLDNA) in solution phase
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DOI：
10.1016/j.tetlet.2009.04.101
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发表时间：
2009-07-15
影响因子：
1.8
通讯作者：
Isobe, Hiroyuki
中科院分区：
文献类型：
--
作者：
Fujino, Tomoko;Yamazaki, Naomi;Isobe, Hiroyuki
发展了一条液相合成三唑连接的寡聚DNA类似物（（TL）DNA）的收敛路线。一锅程序的掩蔽乙炔和随后的铜催化的Huisgen偶联反应的低聚物之间的脱甲硅烷基化允许的7-mer和8-mer（TL）的DNA在良好的产率的液相合成。(C)2009爱思唯尔有限公司保留所有权利。
A convergent route for the solution-phase synthesis of oligomeric triazole-linked analogues of DNA ((TL)DNA) has been developed. A one-pot procedure for desilylation of masked acetylene and the ensuing copper-catalyzed Huisgen coupling reaction between oligomers allowed the solution-phase synthesis of 7-mer and 8-mer (TL)DNA in good yield. (C) 2009 Elsevier Ltd. All rights reserved.