Soyfood intake in the prevention of breast cancer risk in women: A meta-analysis of observational epidemiological studies
Soyfood intake in the prevention of breast cancer risk in women: A meta-analysis of observational epidemiological studies
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DOI：
10.3177/jnsv.52.428
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发表时间：
2006-12-01
影响因子：
1.6
通讯作者：
Hoshi, Kazuhiko
中科院分区：
文献类型：
--
作者：
Qin, Li-Qiang;Xu, Jia-Ying;Hoshi, Kazuhiko
许多研究表明，大豆制品的摄入量可能会防止乳腺癌的发生，因为它们含有大量的大豆酮。为了回顾观察性研究的结果，我们对相关文献进行了荟萃分析。我们在Medline上搜索了1966年1月至2006年4月期间大豆食品消费（或大豆摄入量）与乳腺癌风险之间关系的报告。使用随机效应模型估计合并相对风险（RR）。最终分析纳入了21项独立研究（14项病例对照研究和7项队列研究）。大豆食品摄入量的乳腺癌合并RR为0.75，95%CI为0.59-0.95。作为日本和中国的主要大豆食品，豆腐和味噌表现出明显的保护作用。异黄酮摄入导致风险降低20%（RR=0.81，95%CI 0.67-0.99）。根据研究分层，汇总RR变化不大。当添加日文和中文发表的研究时，大豆食品，豆腐和乳腺癌风险之间的反向关联变得稍微强一些。味噌的弱关联可能是由于味噌汤中的盐浓度高。在当前的分析中，我们没有发现强有力的证据表明这些研究的组合存在发表偏倚。这项荟萃分析支持了大豆食品摄入量可能与降低乳腺癌风险有关的假设。需要进行进一步的流行病学研究，以获得关于大豆食品的更全面的信息，并对大豆酮进行更准确的评估。
Many studies have suggested that the intake of soy products may protect against the occurrence of breast cancer because of the considerable amount of isoflavones they contain. To review the results of the observational studies, we performed this metaanalysis of the relevant literature. We searched Medline for reports that examined the association between soyfood consumption (or isoflavone intake) and breast cancer risk from January 1966 to April 2006. The random-effects model was used to estimate the pooled relative risk (RR). Twenty-one independent studies (14 case-control studies and 7 cohort studies) were included in the final analysis. The pooled RR of breast cancer for soyfood intake was 0.75 with a 95% CI of 0.59-0.95. As the main types of soyfood in Japan and China, tofu and miso showed clear protective effects. Isoflavone intake resulted in a 20% decrease in risk (RR=0.81, 95% CI 0.67-0.99). The pooled RR varied little according to study stratification. When the studies published in Japanese and Chinese were added, the inverse associations between soyfood, tofu and breast cancer risk became slightly stronger. The weak association of miso was possibly due to the high concentration of salt in miso soup. In the present analysis, we did not find strong evidence for publication bias in the combination of the studies. This meta-analysis supported the hypotheses that soyfood intake may be associated with a decreased risk of breast cancer due to the isoflavones. Further epidemiological studies need to be conducted with more comprehensive information about the soyfood, and more accurate assessment of the isoflavones.