STAT transcription factors in normal and cancer stem cells
STAT transcription factors in normal and cancer stem cells
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DOI：
10.1016/j.jbior.2014.05.004
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发表时间：
2014-01-01
影响因子：
--
通讯作者：
Johnson, Daniel E.
中科院分区：
文献类型：
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作者：
Dorritie, Kathleen A.;Redner, Robert L.;Johnson, Daniel E.
信号转导和转录激活蛋白（STAT）在正常造血细胞（包括造血干细胞）的细胞增殖和存活的调节中起重要作用。然而，STAT的异常激活通常在许多血液恶性肿瘤中观察到，并且最近的研究表明，靶向STAT可能在这些疾病中具有治疗益处。更多的研究提供了对白血病起始的细胞（称为白血病干细胞）的更多了解。新出现的证据表明，STAT在维持白血病干细胞方面很重要，并且代表了根除这种危险细胞群的有希望的靶点。在这里，我们总结了什么是已知的正常造血干细胞和白血病干细胞的起源。我们进一步描述了STAT蛋白在这些细胞群体中的作用，以及目前针对STAT蛋白的新型药物和策略的开发进展。(C)2014爱思唯尔有限公司版权所有。
Signal transducer and activator of transcription proteins (STATs) play vital roles in the regulation of cellular proliferation and survival in normal hematopoietic cells, including hematopoietic stem cells. However, aberrant activation of STATs is commonly observed in a number of hematologic malignancies, and recent studies indicate that targeting of STATs may have therapeutic benefit in these diseases. Additional studies have provided greater understanding of the cells responsible for leukemia initiation, referred to as leukemia stem cells. Emerging evidence indicates that STATs are important in maintaining leukemia stem cells and represent a promising target for eradication of this dangerous cell population. Here we summarize what is known about normal hematopoietic stem cells and the origin of leukemic stem cells. We further describe the roles of STAT proteins in these cell populations, as well as current progress toward the development of novel agents and strategies for targeting the STAT proteins. (C) 2014 Elsevier Ltd. All rights reserved.