An open randomized trial comparing disulfiram and naltrexone in adolescents with alcohol dependence
An open randomized trial comparing disulfiram and naltrexone in adolescents with alcohol dependence
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DOI：
10.1080/14659890802305861
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发表时间：
2008-01-01
影响因子：
0.8
通讯作者：
De Sousa, Alan
中科院分区：
文献类型：
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作者：
De Sousa, Avinash;De Sousa, Alan
目的：比较双硫仑(DSF)和纳曲酮(NTX)预防酒依赖青少年酒依赖复发的临床疗效。设计：将58例有家人鼓励服药并随行随访的酒依赖青少年随机分为两组，分别给予DSF或NTX治疗6个月。每周还提供心理教育。精神病学家、患者和家属都知道所开的治疗方案。测量：连续3个月每周记录一次饮酒、渴求和不良事件，然后每两周记录一次。在试验开始和结束时检测血清谷氨酰转移酶(GGT)。结果：试验结束时，仍有54名患者与患者保持联系。DSF的平均复发时间为84天，而NTX为51天。服用DSF的患者中有79.31%的患者保持戒断状态，而服用NTX的患者中有51.72%的患者保持戒断状态。结论：在有良好家庭支持的青少年酒依赖患者中，DSF在预防复发方面优于NTX。在这些药物与心理社会治疗或单独在不同环境中进行进一步比较是有必要的。
Aims: This study aims to compare the efficacy of disulfiram (DSF) and naltrexone (NTX) for preventing alcoholic relapse in adolescents with alcohol dependence in routine clinical practice.Design: 58 adolescents with alcohol dependence having family members that would encourage medical compliance and would accompany them for follow-up were randomly allocated to 6 months of treatment with DSF or NTX. Weekly psycho-education was also provided. The psychiatrist, patient, and family member were aware of the treatment prescribed.Measurements: Alcohol consumption, craving and adverse events were recorded weekly for 3 months and then fortnightly. Serum gamma glutamyl transferase (GGT) was measured at the start and end of the study.Results: At the end of the trial 54 patients were still in contact. Relapse occurred at a mean of 84 days with DSF compared with 51 days for NTX. A total of 79.31% patients on DSF remained abstinent compared with 51.72% with NTX. Patients allocated with NTX however had less craving than the DSF group.Conclusions: DSF was thus found to be superior to NTX in preventing relapse in adolescents with alcohol dependence having good family support. Further comparisons between these drugs along with psychosocial treatments or alone in different settings are warranted.