Tetraspanin-enriched microdomains: The building blocks of migrasomes.
Tetraspanin-enriched microdomains: The building blocks of migrasomes.
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DOI：
10.1016/j.cellin.2021.100003
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发表时间：
2022-02
期刊：
影响因子：
--
通讯作者：
Yu, Li
中科院分区：
文献类型：
--
作者：
Huang, Yuwei;Yu, Li
迁移体是一种新发现的迁移细胞的细胞器。迁移体发挥着多种生理作用，包括线粒体质量控制、细胞间物质的横向转移以及将信号分子递送到空间定义的位置。迁移体的形成依赖于四跨膜蛋白，这是一组包含四个跨膜结构域的膜蛋白，它们形成称为富含四跨膜蛋白的微结构域（TEM）的膜微结构域。在这篇综述中，我们将讨论迁移体生物发生的机制，重点关注 TEM 的作用以及 TEM 形成的组织原则。
The migrasome is a newly discovered organelle of migrating cells. Migrasomes play diverse physiological roles including mitochondrial quality control, lateral transfer of material between cells, and delivery of signaling molecules to spatially defined locations. The formation of migrasomes is dependent on tetraspanins, a group of membrane proteins containing four transmembrane domains, which form membrane microdomains named tetraspanin-enriched microdomains (TEMs). In this review, we will discuss the mechanisms for migrasome biogenesis, with a focus on the role of TEMs and the organizing principles underlying the formation of TEMs.