Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non-Small-Cell Lung Cancer Implications for Therapy
Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non-Small-Cell Lung Cancer Implications for Therapy
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DOI：
10.1097/jto.0b013e318287c3c5
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发表时间：
2013-05-01
影响因子：
20.4
通讯作者：
Gandara, David R.
中科院分区：
文献类型：
--
作者：
Maus, Martin K. H.;Mack, Philip C.;Gandara, David R.
简介：根据最近的临床试验结果，非小细胞肺癌的治疗以组织学为基础的决策已被提倡。我们假设生物标志物切除修复交叉互补1（ERCC1），核糖核苷酸还原酶M1（RRM1）和胸苷酸合成酶（TS）与组织学的相关性是鳞状细胞癌（SCCA）和腺癌（AC）亚型之间化疗结果差异的影响因素。在这里，我们报告分析的反应遗传学公司，方法：如前所述，从显微解剖的福尔马林固定石蜡包埋的肿瘤中提取RNA并进行分析。对2540例非小细胞肺癌患者的标本进行了一种或多种生物标志物的分析，其中1457例被归类为AC或SCCA。
Introduction: On the basis of the results of recent clinical trials, histology-based decision-making for therapy of non-small-cell lung cancer has been advocated. We hypothesized associations of the biomarkers excision repair cross-complementing 1 (ERCC1), ribonucleotide reductase M1 (RRM1), and thymidylate synthase (TS) with histology as a contributing factor to reported differences in chemotherapy outcomes between squamous cell carcinoma (SCCA) and adenocarcinoma (AC) subtypes. Here, we report analysis of the Response Genetics Inc., database and implications for histology-based therapy.Methods: RNA from microdissected formalin-fixed paraffin-embedded tumors was extracted and analyzed as previously described. Specimens from 2540 individual non-small-cell lung cancer patients were analyzed for one or more biomarkers, of which 1457 were categorized as AC or SCCA.Results: For each biomarker, gene expression was lower in AC compared with SCCA (