Atypical valuation of monetary and cigarette rewards in substance dependent smokers
Atypical valuation of monetary and cigarette rewards in substance dependent smokers
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DOI：
10.1016/j.clinph.2015.11.002
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发表时间：
2016-02-01
影响因子：
4.7
通讯作者：
Holroyd, Clay B.
中科院分区：
文献类型：
--
作者：
Baker, Travis E.;Wood, Jonathan M. A.;Holroyd, Clay B.
目的：物质依赖(SD)相对于非依赖(ND)个体表现出一种减弱的奖赏阳性反应，这种电生理信号被认为是前扣带回皮质(ACC)对奖赏敏感性的指标。在这里，我们询问这种改变的神经反应是否反映了相对于AC与药物相关的奖励，货币奖励的特定贬值。方法：我们记录了目前吸烟的SD和ND个体的奖励积极程度，他们在一夜之间戒烟，同时从事两项反馈任务。在金钱条件下，反馈要么是金钱奖励，要么是没有奖励，而在吸烟条件下，反馈要么是与毒品有关的奖励，要么是没有奖励。结果：总的来说，相对于金钱奖励，吸烟引发了更大的奖励正性。此外，对于首先参与金钱条件的被试，SD的奖励正性比ND参与者小，但对于首先从事香烟条件的受试者，SD的奖励正性比ND参与者的大。结论：我们的结果表明，最初的反馈类别“启动”了ACC在随后的实验中对替代反馈类型的反应，SD和ND个体对这种启动效应的反应是不同的。意义：我们提出，对于滥用成瘾物质的人，获得与毒品相关的奖励的前景使ACC对扩展行为施加控制。(C)2015年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Substance dependent (SD) relative to non-dependent (ND) individuals exhibit an attenuated reward positivity, an electrophysiological signal believed to index sensitivity of anterior cingulate cortex (ACC) to rewards. Here we asked whether this altered neural response reflects a specific devaluation of monetary rewards relative to drug-related rewards by ACC.Methods: We recorded the reward positivity from SD and ND individuals who currently smoke, following an overnight period of abstinence, while they engaged in two feedback tasks. In a money condition the feedback indicated either a monetary reward or no reward, and in a cigarette condition the feedback indicated either a drug-related reward or no reward.Results: Overall, cigarette relative to monetary rewards elicited a larger reward positivity. Further, for the subjects who engaged in the money condition first, the reward positivity was smaller for the SD compared to the ND participants, but for the subjects who engaged in the cigarette condition first, the reward positivity was larger for the SD compared to the ND participants.Conclusions: Our results suggest that the initial category of feedback "primed" the response of the ACC to the alternative feedback type on subsequent trials, and that SD and ND individuals responded differently to this priming effect.Significance: We propose that for people who misuse addictive substances, the prospect of obtaining drug-related rewards engages the ACC to exert control over extended behaviors. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.