Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate
Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate
复制标题
高压氧治疗通过降低复发率来提高瘢痕疙瘩手术和放疗的效果
DOI：
10.1631/jzus.b1800132
复制
发表时间：
2018-11-01
影响因子：
5.1
通讯作者：
Wang, Xiao-jun
中科院分区：
文献类型：
--
作者：
Song, Ke-xin;Liu, Shu;Wang, Xiao-jun
瘢痕疙瘩是由于损伤后纤维组织的异常生长而形成的旺盛的皮肤疤痕。本研究的主要目的是评估高压氧治疗(HBOT)降低手术切除和放疗后瘢痕疙瘩复发率的效果和机制。(1)240例患者随机分为两组。HBOT组(O组)在手术切除加放疗后接受HBOT治疗。另一组单纯手术切除加放疗(K组)。(2)二次手术后收集复发患者的瘢痕组织。苏木精-伊红染色观察瘢痕疙瘩形态。免疫组织化学染色检测白细胞介素6(IL-6)、低氧诱导因子-1α(α)、肿瘤坏死因子-α(肿瘤坏死因子-α)、核因子-κB(NF-κB)和血管内皮生长因子(VEGFR)。(1)O组复发率(5.97%)明显低于K组(14.15%)，P<；0.05。此外，O组患者的满意度高于K组(P<；0.05)。(2)与K组复发性瘢痕组织相比，O组复发性瘢痕组织中炎症因子的表达水平较低。辅助性高压氧通过提高组织含氧量，减轻炎症过程，有效降低手术切除和放疗后瘢痕疙瘩的复发率。
Keloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy. (1) A total of 240 patients were randomly divided into two groups. Patients in the HBOT group (O group) received HBOT after surgical excision and radiotherapy. Patients in the other group were treated with only surgical excision and radiotherapy (K group). (2) Scar tissue from recurrent patients was collected after a second operation. Hematoxylin and eosin (H&E) staining was used to observe keloid morphology. Certain inflammatory factors (interleukin-6 (IL-6), hypoxia-inducible factor-1α (HIF-1α), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and vascular endothelial growth factor (VEGF)) were measured using immunohistochemical staining. (1) The recurrence rate of the O group (5.97%) was significantly lower than that of the K group (14.15%), P<0.05. Moreover, patients in the O group reported greater satisfaction than those in the K group (P<0.05). (2) Compared with the recurrent scar tissue of the K group, the expression levels of the inflammatory factors were lower in the recurrent scar tissue of the O group. Adjunctive HBOT effectively reduces the keloid recurrence rate after surgical excision and radiotherapy by improving the oxygen level of the tissue and alleviating the inflammatory process.