Evoked Potentials in Motor Cortical Local Field Potentials Reflect Task Timing and Behavioral Performance
Evoked Potentials in Motor Cortical Local Field Potentials Reflect Task Timing and Behavioral Performance
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DOI：
10.1152/jn.00250.2010
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发表时间：
2010-11-01
影响因子：
2.5
通讯作者：
Riehle, Alexa
中科院分区：
文献类型：
--
作者：
Kilavik, Bjorg Elisabeth;Confais, Joachim;Riehle, Alexa
Kilavik BE、Confais J、Ponce-Alvarez A、Diesmann M、Riehle A。运动皮层局部场电位的诱发电位反映了任务计时和行为表现。 J Neurophysiol 104: 2338-2351, 2010。首次发表于 2010 年 9 月 8 日； doi：10.1152/jn.00250.2010。诱发电位 (EP) 在运动执行期间（运动相关电位 [MRP]）和响应相关视觉线索（视觉诱发电位 [VEP]）时在运动皮层局部场电位 (LFP) 中观察到。运动皮质 EP 可能具有方向选择性，但人们对它们与运动行为其他方面（例如任务时间和表现）的关系知之甚少。我们记录了两只猴子在执行预先准备的伸臂任务期间运动皮层的 LFP。每次试验开始时的时间提示表明延迟持续时间，从而表明任务的节奏和运动准备的可用时间。 VEP 和 MRP 受到延迟持续时间的强烈调节，短延迟试验中 VEP 系统性较大，长延迟试验中 MRP 较大。尽管这些系统调节与任务时间相关，但短期和长期试验中的方向选择性是相似的。在会话内，行为反应时间与 MRP 大小呈正相关，与 VEP 大小呈负相关。此外，随着 VEP 和 MRP 大小的缓慢减小，各会话的行为表现也有所改善。我们的结果清楚地表明，在运动准备和执行过程中，行为背景和表现对运动皮质群活动的强烈影响。
Kilavik BE, Confais J, Ponce-Alvarez A, Diesmann M, Riehle A. Evoked potentials in motor cortical local field potentials reflect task timing and behavioral performance. J Neurophysiol 104: 2338-2351, 2010. First published September 8, 2010; doi:10.1152/jn.00250.2010. Evoked potentials (EPs) are observed in motor cortical local field potentials (LFPs) during movement execution (movement-related potentials [MRPs]) and in response to relevant visual cues (visual evoked potentials [VEPs]). Motor cortical EPs may be directionally selective, but little is known concerning their relation to other aspects of motor behavior, such as task timing and performance. We recorded LFPs in motor cortex of two monkeys during performance of a precued arm-reaching task. A time cue at the start of each trial signaled delay duration and thereby the pace of the task and the available time for movement preparation. VEPs and MRPs were strongly modulated by the delay duration, VEPs being systematically larger in short-delay trials and MRPs larger in long-delay trials. Despite these systematic modulations related to the task timing, directional selectivity was similar in short and long trials. The behavioral reaction time was positively correlated with MRP size and negatively correlated with VEP size, within sessions. In addition, the behavioral performance improved across sessions, in parallel with a slow decrease in the size of VEPs and MRPs. Our results clearly show the strong influence of the behavioral context and performance on motor cortical population activity during movement preparation and execution.