TGF-β1 Promotes Migration and Invasion of Salivary Adenoid Cystic Carcinoma
TGF-β1 Promotes Migration and Invasion of Salivary Adenoid Cystic Carcinoma
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DOI：
10.1177/0022034511401407
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发表时间：
2011-06-01
影响因子：
7.6
通讯作者：
Wang, C. Y.
中科院分区：
文献类型：
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作者：
Dong, L.;Wang, Y. X.;Wang, C. Y.
涎腺腺样囊性癌(SACC)是涎腺癌中最常见的亚型之一，常转移至远处器官。然而，目前对促进SACC转移的分子机制知之甚少。在这项研究中，我们报告了转化生长因子-β1在高转移的SACC-LM细胞系中的高表达，与其亲代低转移的SACC-83细胞系相比。外源性加入转化生长因子-β1可诱导Smad2磷酸化，促进SACC-83细胞的迁移和侵袭。一直以来，一种针对I型转化生长因子-β1受体(TβRI)的抑制剂抑制SACC-LM细胞的内源性转化生长因子-β1信号，抑制了细胞的迁移和侵袭。此外，我们还发现在有转移的人原发SACC标本中，转化生长因子-β1的表达显著增加。综上所述，我们的结果提示，转化生长因子-β1可能在SACC转移中起关键作用。
Salivary adenoid cystic carcinoma (SACC) is one of the most common subtypes of salivary gland carcinomas and frequently metastasizes to distant organs. However, little is known about the molecular mechanisms that promote SACC metastasis. In this study, we report that transforming growth factor (TGF)-beta 1 was highly expressed in the highly metastatic SACC-LM cell line as compared with its parental low-metastatic SACC-83 cell line. Exogenous addition of TGF-beta 1 induced Smad2 phosphorylation and promoted the migration and invasion of SACC-83 cells. Consistently, the inhibition of endogenous TGF-beta 1 signaling in SACC-LM cells by an inhibitor specific to the type I TGF-beta 1 receptor (T beta RI) suppressed cell migration and invasion. Moreover, we found that TGF-beta 1 expression was significantly increased in human primary SACC samples with metastasis. Taken together, our results suggest that TGF-beta 1 may play a crucial role in SACC metastasis.