Induction of an interdigitated gel phase in fully hydrated phosphatidylcholine bilayers
Induction of an interdigitated gel phase in fully hydrated phosphatidylcholine bilayers
复制标题
在完全水合的磷脂酰胆碱双层中诱导交错凝胶相
DOI：
10.1016/0005-2736(83)90403-0
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. Simon
中科院分区：
文献类型：
--
作者：
T. McIntosh;R. McDaniel;S. Simon
几种表面活性小分子在二棕榈酰磷脂酰胆碱 (DPPC) 悬浮液中诱导不寻常的相。在此阶段，来自并置单层的脂质烃链相互渗透或叉指。 X 射线衍射结构分析表明，掺入药物氯丙嗪后，DPPC 脂质体中的双层厚度或脂质头基分离仅为 30 Å，比两个完全延伸的 DPPC 分子小约 20 Å。这种叉指相可能是比以前认为的更普遍的现象，因为其他几种分子，无论带电还是不带电，例如丁卡因和苯甲醇，都可以导致脂质烃链相互渗透。
Several surface active small molecules induce an unusual phase in dipalmitoylphosphatidylcholine (DPPC) suspensions. In this phase, the lipid hydrocarbon chains from apposing monolayers interpenetrate or interdigitate. A structural analysis by X-ray diffraction shows that with incorporation of the drug chlorpromazine, the bilayer thickness, or lipid headgroup separation, in DPPC liposomes is only 30 Å, which is about 20 Å smaller than two fully-extended DPPC molecules. This interdigitated phase may be a more general phenomenon than previously believed, as several other molecules, both charged and uncharged, such as tetracaine and benzyl alcohol, can cause the lipid hydrocarbon chains to interpenetrate.
影响因子：
2.9
作者：
McDaniel,RV;Simon,SA;McIntosh,TJ;Borovyagin,V
通讯作者：
Borovyagin,V