Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities.
Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities.
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DOI：
10.1007/s00109-015-1345-4
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Lynch CC
中科院分区：
文献类型：
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作者：
Shay G;Hazlehurst L;Lynch CC
多发性骨髓瘤是一种浆细胞骨骼恶性肿瘤。虽然硼替佐米和来那度胺等治疗剂显著改善了总体生存率，但该疾病目前无法治愈，耐药性的出现限制了化疗策略的疗效。未能治愈这种疾病的部分原因是癌症的潜在遗传异质性。骨髓瘤的进展严重依赖于周围的微环境。确定骨髓瘤细胞与骨微环境中遗传更稳定的造血和间充质成分之间的相互作用对于开发新的治疗靶点至关重要。在这篇综述中，我们讨论了我们对微环境元素如何促进骨髓瘤进展的理解的最新进展，以及这些元素如何能够或目前正在被靶向以根除疾病。
Multiple myeloma is a plasma cell skeletal malignancy. While therapeutic agents such as bortezomib and lenalidomide have significantly improved overall survival, the disease is currently incurable with the emergence of drug resistance limiting the efficacy of chemotherapeutic strategies. Failure to cure the disease is in part due to the underlying genetic heterogeneity of the cancer. Myeloma progression is critically dependent on the surrounding microenvironment. Defining the interactions between myeloma cells and the more genetically stable hematopoietic and mesenchymal components of the bone microenvironment is critical for the development of new therapeutic targets. In this review, we discuss recent advances in our understanding of how microenvironmental elements contribute to myeloma progression and therapeutically, how those elements can or are currently being targeted in a bid to eradicate the disease.