The Relationship Between Waist Circumference and the Risk of Stroke and Myocardial Infarction in a Japanese Urban Cohort The Suita Study
The Relationship Between Waist Circumference and the Risk of Stroke and Myocardial Infarction in a Japanese Urban Cohort The Suita Study
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DOI：
10.1161/strokeaha.109.569145
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发表时间：
2010-03-01
期刊：
影响因子：
8.3
通讯作者：
Date, Chigusa
中科院分区：
文献类型：
--
作者：
Furukawa, Yoko;Kokubo, Yoshihiro;Date, Chigusa
背景和目的-体重指数最常用作为肥胖指数。最近，腰围（WC）已被证明与心血管疾病（CVD）的风险相关。然而，在日本尚无研究观察到 WC 与 CVD 之间存在关联。我们研究了日本城市人口中 WC 和体重指数与 CVD 的关系。方法 - 我们研究了 5474 名日本人（基线时年龄为 30 至 79 岁，无 CVD），他们完成了基线调查并在 2005 年 12 月之前接受了随访。 WC 是在参与者站立位置的脐部水平测量的，精确到 1 厘米。调整年龄、吸烟和饮酒状况后，根据 WC 四分位数计算 CVD 的 Cox 比例风险比。 结果 - 在平均 11.7 年的随访期间，记录了 207 例中风和 133 例心肌梗塞。在女性中，与最低四分位数（WC < 70 cm）相比，调整年龄、吸烟和饮酒后，最高四分位数（WC >= 84 cm）的CVD风险比（95% CI）为1.85（1.03至3.31），中风为2.64（1.16至6.03）。然而，在男性中没有观察到 WC 与 CVD 或中风风险的这种关系。进一步调整高血压、糖尿病和高胆固醇血症后，上述关系均无统计学意义。没有观察到体重指数与 CVD 或中风之间的关联。结论-WC 可能是日本女性 CVD 或中风的更好预测指标。 （中风。2010；41：550-553。）
Background and Purpose-Body mass index is most commonly used as the obesity index. Recently, waist circumference (WC) has been shown to be associated with the risk of cardiovascular disease (CVD). However, no studies have observed an association between WC and CVD in Japan. We examined the relationships of WC and body mass index with CVD in a Japanese urban population.Methods-We studied 5474 Japanese individuals (aged 30 to 79 years without CVD at baseline) who completed a baseline survey and received follow-up through December 2005. WC was measured at the umbilical level of participants in the standing position to the nearest 1 cm. The Cox proportional hazard ratios for CVD according to the quartiles of WC were calculated after adjustment for age, smoking, and drinking status.Results-During a mean follow-up of 11.7 years, 207 strokes and 133 myocardial infarctions were documented. In women, compared with the lowest quartile (WC < 70 cm), the hazard ratio (95% CIs) after adjusting for age, smoking, and drinking in the highest quartile (WC >= 84 cm) were 1.85 (1.03 to 3.31) for CVD and 2.64 (1.16 to 6.03) for stroke. However, no such relationships of WC with CVD or stroke risk were observed in men. After further adjustment of hypertension, diabetes, and hypercholesterolemia, all of the mentioned relationships were not statistically significant. No associations of body mass index with CVD or strokes were observed.Conclusions-WC may be a better predictor for CVD or stroke in Japanese women. (Stroke. 2010;41:550-553.)