Membrane interactions and antimicrobial effects of inorganic nanoparticles
Membrane interactions and antimicrobial effects of inorganic nanoparticles
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DOI：
10.1016/j.cis.2017.07.029
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发表时间：
2017-10-01
影响因子：
15.6
通讯作者：
Malmsten, Martin
中科院分区：
文献类型：
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作者：
Haffner, Sara Malekkhaiat;Malmsten, Martin
纳米颗粒和生物膜之间的相互作用在当前纳米医学中引起了越来越多的关注，并且对于纳米毒理学和在诊断、药物递送、功能性生物材料以及这些的组合中利用纳米材料都起着关键作用，例如，在治疗诊断学上此外，由于对传统抗生素的耐药性增加，目前对使用纳米材料作为抗菌剂的兴趣相当大。在这里，各种纳米材料为触发功能分子提供了对抗挑战性感染的机会。尽管这些不同应用中的性能受纳米材料、所含药物的性质（如果有的话）和生物系统之间复杂的相互作用的影响，但纳米颗粒-膜相互作用构成了关键的初始步骤，并对随后的生物反应起着关键作用。在本概述中，概述了目前对无机纳米材料作为抗微生物剂的理解，特别关注抗微生物效果和膜相互作用之间的相互作用，以及这些材料的膜相互作用和抗微生物效果如何取决于纳米颗粒特性、膜组成和外部（例如，光和磁）场。(C)2017爱思唯尔B. V.保留所有权利。
Interactions between nanoparticles and biological membranes are attracting increasing attention in current nanomedicine, and play a key role both for nanotoxicology and for utilizing nanomaterials in diagnostics, drug delivery, functional biomaterials, as well as combinations of these, e.g., in theranostics. In addition, there is considerable current interest in the use of nanomaterials as antimicrobial agents, motivated by increasing resistance development against conventional antibiotics. Here, various nanomaterials offer opportunities for triggered functionalites to combat challenging infections. Although the performance in these diverse applications is governed by a complex interplay between the nanomaterial, the properties of included drugs (if any), and the biological system, nanoparticle-membrane interactions constitute a key initial step and play a key role for the subsequent biological response. In the present overview, the current understanding of inorganic nanomaterials as antimicrobial agents is outlined, with special focus on the interplay between antimicrobial effects and membrane interactions, and how membrane interactions and antimicrobial effects of such materials depend on nano particle properties, membrane composition, and external (e.g., light and magnetic) fields. (C) 2017 Elsevier B.V. All rights reserved.