Risk factors for visual field damage progression in normal-tension glaucoma eyes
Risk factors for visual field damage progression in normal-tension glaucoma eyes
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DOI：
10.1007/s004170050203
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发表时间：
1999-02-01
影响因子：
2.7
通讯作者：
Kitazawa, Y
中科院分区：
文献类型：
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作者：
Daugeliene, L;Yamamoto, T;Kitazawa, Y
背景：本研究旨在评估与正常眼压性青光眼（NTG）眼视野损伤进展相关的眼内或全身因素。患者和方法：回顾性研究纳入了 47 只 NTG 眼，随访时间至少为 5 年。进行逐步回归分析以将视野损伤进展（表示为每年平均偏差（MD）变化）与几个独立的临床因素相关联，包括年龄、椎间盘出血史、初始MD、平均眼压（IOP）、峰值IOP、IOP的昼夜波动、视乳头周围萎缩的β区的存在以及Ca2+通道阻滞剂的使用。结果：统计分析显示，不使用Ca2+通道阻滞剂（P=0.01）、视乳头周围萎缩（P=0.03）和椎间盘出血（P=0.04）与视力丧失进展相关。结论：与眼压无关的危险因素被认为与视野丧失的进展有关。全身使用Ca2+通道阻滞剂对NTG眼的视野预后有良好的影响。
Background: This study was carried out to evaluate intraocular or systemic factors associated with the visual field damage progression in eyes with normal-tension glaucoma (NTG). Patients and methods: Forty-seven NTG eyes with a minimum follow-up of 5 years were enrolled into the retrospective study. A stepwise regression analysis was performed to correlate the visual field damage progression, expressed as the mean deviation (MD) change per year, with several independent clinical factors including age, history of disc hemorrhage, initial MD, mean intraocular pressure (IOP), peak IOP, diurnal fluctuation of IOP, presence of a beta zone of peripapillary atrophy, and use of Ca2+-channel blockers. Results: Statistical analysis revealed that non-use of Ca2+-channel blockers (P=0.01), peripapillary atrophy (P=0.03) and disc hemorrhage (P=0.04) were associated with visual loss progression. Conclusions: Risk factors unrelated to IOP were suggested to be associated with progression of visual field loss. Systemic use of Ca2+-channel blockers has a favorable effect on visual field prognosis in NTG eyes.