Weight loss: A determinant of hip bone loss in older men and women - The Rancho Bernardo Study
Weight loss: A determinant of hip bone loss in older men and women - The Rancho Bernardo Study
复制标题
DOI：
10.1093/aje/kwg265
复制
发表时间：
2003-12-15
影响因子：
5
通讯作者：
Barrett-Connor, E
中科院分区：
文献类型：
--
作者：
Knoke, JD;Barrett-Connor, E
体重变化对髋骨总矿物质密度变化的性别特异性影响在 4 年（1992-1996 年）内对 1,214 名基线平均年龄为 71 岁的社区居住成年人进行了评估。在两次研究访视中评估体重和骨矿物质密度（通过双能 X 射线骨密度测定法）。男女平均每年骨质流失 0.5%； 29% 的男性和 28% 的女性每年至少损失 1% 的骨矿物质密度。超过五分之一的参与者每年体重至少减轻 1%（男性为 21%，女性为 23%）。这些减肥者每年骨质流失至少 1% 的可能性是其他人的两倍。在控制年龄、基线体重和生活方式的分析中，体重减轻是骨质流失最强的独立预测因素（男性比值比为 1.53，女性比值比为 1.56）。每年体重减轻至少 1% 的人更有可能在第二次就诊时报告健康状况良好或较差，且功能受限，并在第二次就诊后 2 年内死亡；然而，大多数人并没有报告健康状况恶化，而且大多数人至少还存活了两年。
The sex-specific effect of weight change on change in total hip bone mineral density was evaluated over 4 years (1992-1996) in 1,214 community-dwelling adults whose mean age at baseline was 71 years. Weight and bone mineral density (by dual-energy x-ray absorptiometry) were assessed at two study visits. The average bone loss was 0.5% per year in both sexes; 29% of men and 28% of women lost at least 1% of bone mineral density per year. More than one in five participants lost at least 1% of their body weight per year (21% of men and 23% of women). These weight losers were twice as likely as others to lose bone at the rate of at least 1% per year. In analyses controlling for age, baseline weight, and lifestyle, weight loss was the strongest independent predictor of bone loss (odds ratios were 1.53 for men and 1.56 for women). Persons with weight loss of at least 1% per year were more likely to report fair or poor health and functional limitation at the second visit and to die within 2 years of the second visit; however, most did not report declining health, and most survived for at least 2 additional years.