Cognitive differences between early- and late-onset Alzheimer's disease.
Cognitive differences between early- and late-onset Alzheimer's disease.
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DOI：
10.1177/1533317506299156
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发表时间：
2007-06-01
期刊：
影响因子：
--
通讯作者：
Mendez, Mario F
中科院分区：
文献类型：
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作者：
Licht, Eliot A;McMurtray, Aaron M;Mendez, Mario F
尽管神经病理学研究表明早发性阿尔茨海默病（EAD）和“老年性痴呆”无法区分，但临床研究表明EAD和晚发性阿尔茨海默病（LAD）在认知上是不同的。我们试图通过比较发病年龄极端的患者来调查 EAD 和 LAD 是否在认知上存在差异，以便最大化可能区分它们的特征。我们对 44 名患有 EAD 的男性（发病年龄小于 65 岁）和 44 名患有 LAD 的男性（发病年龄为 84 岁或以上）进行了初步就诊时的摄入认知筛查检查。 EAD 组和 LAD 组在痴呆或大多数认知变量方面没有差异。与EAD相比，LAD组的言语流畅性和运动执行功能较差。当考虑到年龄差异时，这些差异就消失了。我们得出的结论是，阿尔茨海默病是一种临床异质性疾病，其表现可能随发病年龄而变化。这些差异表明这种疾病与年龄相关的脆弱性。
Although neuropathologic studies showed that early-onset Alzheimer's disease (EAD) and "senile dementia" were indistinguishable, clinical studies suggested that EAD and late-onset Alzheimer's disease (LAD) were cognitively distinct. We sought to investigate whether EAD and LAD are cognitively different by comparing patients at the extremes of the ages of onset in order to maximize features that might separate them. We compared 44 men with EAD (age of onset less than 65 years) with 44 men with LAD (age of onset 84 years or older) on an intake cognitive screening examination on initial presentation. The EAD and LAD groups did not differ on dementia or most cognitive variables. Compared with EAD, the LAD group had worse verbal fluency and motor-executive functions. These differences disappeared when age differences were taken into account. We conclude that Alzheimer's disease is a clinically heterogeneous disorder whose manifestations can vary with age of onset. These differences indicate age-related vulnerabilities in this disease.