Integrated analysis of two-lncRNA signature as a potential prognostic biomarker in cervical cancer: a study based on public database
Integrated analysis of two-lncRNA signature as a potential prognostic biomarker in cervical cancer: a study based on public database
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两种lncRNA特征作为宫颈癌潜在预后生物标志物的综合分析：基于公共数据库的研究
DOI：
10.7717/peerj.6761
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发表时间：
2019-04-22
期刊：
影响因子：
2.7
通讯作者：
Liang, Geyu
中科院分区：
文献类型：
--
作者：
Wu, Wenjuan;Sui, Jing;Liang, Geyu
背景：宫颈癌（CC）是世界范围内妇女常见的妇科恶性肿瘤。有证据表明，长链非编码RNA（lncRNA）可用作CC患者的生物标志物。然而，CC的预后生物标志物仍然缺乏。本研究的目的是根据美国癌症基因组图谱（TCGA）的数据，寻找能预测CC预后的lncRNA生物标志物。基于倍数变化>2，在CC组织中与相邻正常组织相比鉴定了差异表达的lncRNA，
Background: Cervical cancer (CC) is a common gynecological malignancy in women worldwide. Evidence suggests that long non-coding RNAs (lncRNAs) can be used as biomarkers in patients with CC. However, prognostic biomarkers for CC are still lacking. The aim of our study was to find lncRNA biomarkers which are able to predict prognosis in CC based on the data from The Cancer Genome Atlas (TCGA).Methods: The patients were divided into three groups according to FIGO stage. Differentially expressed lncRNAs were identified in CC tissue compared to adjacent normal tissues based on a fold change >2 and