Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
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DOI：
10.1073/pnas.191355898
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发表时间：
2001-09-25
影响因子：
11.1
通讯作者：
Zatorre, RJ
中科院分区：
文献类型：
--
作者：
Blood, AJ;Zatorre, RJ
我们使用正电子发射断层扫描来研究对音乐的激烈情绪反应的神经机制。响应于主题选择的音乐来测量脑血流的变化，这引起了“湿透的脊柱”或“寒意”的高度愉悦的体验。寒意的主观报道伴随着心率，肌电图和呼吸的变化。随着这些寒冷的强度的增加，在被认为与奖励/动机，情感和唤醒有关的大脑区域中观察到大脑血流的增加，包括腹侧纹状体，中脑，杏仁核，甲状腺甲状腺皮质和腹侧前额叶前额叶皮质。已知这些大脑结构对其他引起大快乐刺激的刺激（例如食物，性别和滥用药物）是活跃的。这一发现将音乐与与生物学相关的，与生存相关的刺激联系起来，通过他们对娱乐和奖励涉及的脑电路的共同招募。
We used positron emission tomography to study neural mechanisms underlying intensely pleasant emotional responses to music. Cerebral blood flow changes were measured in response to subject-selected music that elicited the highly pleasurable experience of "shivers-down-the-spine" or "chills." Subjective reports of chills were accompanied by changes in heart rate, electromyogram, and respiration. As intensity of these chills increased, cerebral blood flow increases and decreases were observed in brain regions thought to be involved in reward/motivation, emotion, and arousal, including ventral striatum, midbrain, amygdala, orbitofrontal cortex, and ventral medial prefrontal cortex. These brain structures are known to be active in response to other euphoria-inducing stimuli, such as food, sex, and drugs of abuse. This finding links music with biologically relevant, survival-related stimuli via their common recruitment of brain circuitry involved in pleasure and reward.