Breakdown of Filamentous Myofibrils by the UPS-Step by Step.
Breakdown of Filamentous Myofibrils by the UPS-Step by Step.
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DOI：
10.3390/biom11010110
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发表时间：
2021-01-15
期刊：
影响因子：
5.5
通讯作者：
Cohen S
中科院分区：
文献类型：
--
作者：
Aweida D;Cohen S
蛋白质降解通过调节几乎所有的生物过程来维持细胞的完整性，而受损的蛋白质水解会扰乱蛋白质质量控制，并经常导致人类疾病。两种主要的蛋白质水解系统负责所有细胞中的蛋白质分解：自噬，它促进细胞器、蛋白质聚集体和细胞表面蛋白质的损失；以及促进主要可溶性蛋白质降解的泛素-蛋白酶体系统（UPS）。最近的研究结果表明，更复杂的蛋白质结构，如丝状组合，在体外蛋白酶体的催化核心无法接触到，可以在体内系统分解代谢状态下被这种蛋白质水解机制有效地降解。放松丝状结构的机制似乎首先被激活，因此增加了蛋白质成分对UPS的可及性。在这篇综述中，我们将讨论复杂的不溶性丝状肌原纤维的分解和丢失的机制，这些丝状肌原纤维负责肌肉收缩，其被UPS降解导致衰老和疾病中的虚弱和残疾。一些证据表明，肌原纤维的分解是在严格有序和控制的方式下发生的，而aaa - atp酶的功能对它们的分解和损失至关重要。
Protein degradation maintains cellular integrity by regulating virtually all biological processes, whereas impaired proteolysis perturbs protein quality control, and often leads to human disease. Two major proteolytic systems are responsible for protein breakdown in all cells: autophagy, which facilitates the loss of organelles, protein aggregates, and cell surface proteins; and the ubiquitin-proteasome system (UPS), which promotes degradation of mainly soluble proteins. Recent findings indicate that more complex protein structures, such as filamentous assemblies, which are not accessible to the catalytic core of the proteasome in vitro, can be efficiently degraded by this proteolytic machinery in systemic catabolic states in vivo. Mechanisms that loosen the filamentous structure seem to be activated first, hence increasing the accessibility of protein constituents to the UPS. In this review, we will discuss the mechanisms underlying the disassembly and loss of the intricate insoluble filamentous myofibrils, which are responsible for muscle contraction, and whose degradation by the UPS causes weakness and disability in aging and disease. Several lines of evidence indicate that myofibril breakdown occurs in a strictly ordered and controlled manner, and the function of AAA-ATPases is crucial for their disassembly and loss.
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影响因子：
2.7
作者：
Bouvet M;Dubois-Deruy E;Alayi TD;Mulder P;El Amranii M;Beseme O;Amouyel P;Richard V;Tomavo S;Pinet F
通讯作者：
Pinet F
影响因子：
9
作者：
Bossola, M;Muscaritoli, M;Baccino, FM
通讯作者：
Baccino, FM
影响因子：
10.8
作者：
Chen, Zhenyue;Huang, Wei;Xu, Xiaolei
通讯作者：
Xu, Xiaolei
影响因子：
4.8
作者：
Coyne, Erin S.;Bedard, Nathalie;Wing, Simon S.
通讯作者：
Wing, Simon S.
DOI：
10.1083/jcb.201110067
发表时间：
2012-08-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cohen S;Zhai B;Gygi SP;Goldberg AL
通讯作者：
Goldberg AL