Inhibition of Ice Crystal Growth by Synthetic Glycopolymers: Implications for the Rational Design of Antifreeze Glycoprotein Mimics
Inhibition of Ice Crystal Growth by Synthetic Glycopolymers: Implications for the Rational Design of Antifreeze Glycoprotein Mimics
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DOI：
10.1021/bm801069x
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发表时间：
2009-02-01
影响因子：
6.2
通讯作者：
Cameron, Neil R.
中科院分区：
文献类型：
--
作者：
Gibson, Matthew I.;Barker, Carl A.;Cameron, Neil R.
一系列结构不同的聚合物，含有肽或乙烯基衍生的主链，进行了测试的冰重结晶抑制活性，这是通常与抗冻（糖）蛋白。结果表明，只有侧链上带有羟基的聚合物才能抑制冰的生长。此外，定义明确的糖共聚物显示出具有小但显著的重结晶抑制作用，表明可以基于衍生自乙烯基单体的聚合物来设计抗冻糖蛋白模拟物。
A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth. Furthermore, well-defined glycopolymers were shown to have a small but significant recrystallization inhibition effect, showing that it may be possible to design antifreeze glycoprotein mimics based upon polymers derived from vinyl monomers.