In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis
In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis
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DOI：
10.1136/gut.51.1.21
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发表时间：
2002-07-01
期刊：
影响因子：
24.5
通讯作者：
Macpherson, AJ
中科院分区：
文献类型：
--
作者：
Bridger, S;Lee, JCW;Macpherson, AJ
背景和目的：吸烟对不同形式的炎症性肠病（IBD）有相反的影响。它易导致克罗恩病（CID）的发展，但与溃疡性结肠炎(K)的发病率降低有关。我们研究了吸烟和IBD表型（UC或CID）不一致的兄弟姐妹对，以研究吸烟是否决定了具有非常相似遗传易感性的个体发生的IBD类型。患者：分析242例IBD家系（658例）的吸烟习惯和疾病特征。在这一组中，有339对受影响的兄弟姐妹，其中89对在诊断时吸烟不一致。结果：诊断时吸烟与CID的发展相关(优势比（OR） 3.55；95%置信限2.50-5.02；p
Background and aims: Smoking tobacco has opposite effects on the different forms of inflammatory bowel disease (IBD). It predisposes to the development of Crohn's disease (CID) yet is associated with a reduced incidence of ulcerative colitis (K). We have studied sib pairs discordant for both smoking and IBD phenotype (UC or CID) to investigate whether smoking determines the type of IBD that develops in individuals with very similar genetic susceptibility.Patients: Smoking habits and disease characteristics were analysed in 242 IBD pedigrees (658 patients). Within this group there were 339 affected sibling pairs of whom 89 were discordant for smoking when diagnosed.Results: Smoking at diagnosis was associated with development of CID (odds ratio (OR) 3.55; 95% confidence limits 2.50-5.02; p