Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance
Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance
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DOI：
10.1530/eje-19-0684
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发表时间：
2020-02-01
影响因子：
5.8
通讯作者：
Perello, Mario
中科院分区：
文献类型：
--
作者：
Fittipaldi, Antonela S.;Hernandez, Julieta;Perello, Mario
目的：辛酰化肽激素生长素释放肽调节食欲和血糖控制。去酰基生长素释放肽消除生长素释放肽的一些作用，但不与生长素释放肽受体结合。 LEAP2 是一种新型胃饥饿素受体配体，可阻断胃饥饿素的作用。一些证据表明，这些肽的血浆水平在成人肥胖症患者中发生了改变，但它们在儿童肥胖症中的水平仍然缺乏研究。因此，本研究的目的是评估正常体重、超重/肥胖儿童的 ghrelin、des-acyl ghrelin 和 LEAP2 空腹血浆水平及其与不同人体测量和代谢变量的相关性。设计：总共 42 名女性和 40 名男性，年龄 3-12 岁作为横断面队列入组。结果：des-acyl ghrelin 和 LEAP2 的血浆水平（但不是超重/肥胖儿童的生长素释放肽）较低，而生长素释放肽/去酰基生长素释放肽比率较高。去酰基生长素释放肽与年龄、BMI z 评分、胰岛素和 HOMA 指数呈负相关，且在超重/肥胖儿童中相关性更强。 LEAP2 水平与 BMI z 分数呈负相关。未发现性别差异。结论：我们的研究结果表明，由于去酰基生长素释放肽和 LEAP2 血浆水平降低，儿童肥胖症中生长素释放肽张力增加，并且去酰基生长素释放肽与胰岛素抵抗相关，特别是在超重/肥胖的儿童中。
Objective: The octanoylated peptide hormone ghrelin regulates appetite and glycaemic control. Des-acyl ghrelin abolishes some effects of ghrelin, but does not bind to ghrelin receptor. LEAP2 is a novel ligand for ghrelin receptor that blocks the effects of ghrelin. Some evidences show that plasma levels of these peptides are altered in adults with obesity, but their levels in childhood obesity remain poorly studied. Therefore, the objective of this study was to assess fasting plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with normoweight, overweight/obesity and their association with different anthropometric and metabolic variables.Design: A total of 42 females and 40 males, ages 3-12 years old were enrolled as a cross-sectional cohort.Results: Plasma levels of des-acyl ghrelin and LEAP2 (but not ghrelin) were lower and ghrelin/des-acyl ghrelin ratio was higher in children with overweight/obesity. Des-acyl ghrelin negatively correlated with age, BMI z-score, insulin and HOMA index, and the correlations were stronger in children with overweight/obesity. LEAP2 levels negatively correlated with BMI z-score. No gender differences were found.Conclusions: Our findings suggest that ghrelin tone is increased in childhood obesity, due to a decrease on plasma levels of des-acyl ghrelin and LEAP2, and that des-acyl ghrelin is associated to insulin resistance, particularly in children with overweight/obesity.