Low protein Z levels in patients with peripheral arterial disease
Low protein Z levels in patients with peripheral arterial disease
复制标题
外周动脉疾病患者的蛋白质 Z 水平较低
作者：
F. Sofi;F. Cesari;G. Pratesi;A. Cellai;R. Pulli;C. Pratesi;G. Gensini;R. Abbate;S. Fedi
摘要 关于 Z 蛋白与动脉粥样硬化疾病之间的关联，已有相互矛盾的发现。本病例对照研究的目的是评估 Z 蛋白在动脉粥样硬化外周定位中的作用。我们研究了佛罗伦萨大学血管外科中心收治的具有外周动脉疾病 (PAD) 临床表现的 120 名患者（102 名男性，18 名女性；中位年龄：75 岁）以及 360 名年龄和性别与患者组相当的健康受试者的蛋白质 Z 水平。与健康对照组 [1,728 (300–3,736) ng/ml] 相比，PAD 患者的蛋白 Z 水平显着降低 (p < 0.05) [1,594 (89–3,635) ng/ml]。逻辑回归分析显示，在单变量分析中，蛋白 Z 水平低的患者 (<我们对照组的第 5 个百分位：< 601) 的 PAD 风险显着增加ng/ml）（OR：5.72，95%CI 3.07–10.66；p < 0.0001）。调整年龄、性别和传统心血管危险因素后，证实了这种关联（OR：5.83，95%CI 2.83-12.01；p < 0.0001）。此外，在调整年龄、性别和传统心血管危险因素后，通过 Fontaine 分期评估，低蛋白 Z 水平与疾病的临床严重程度之间存在显着相关性（一般线性模型，趋势 p：0.03）。总之，我们的数据显示低蛋白质 Z 水平与 PAD 的发生之间存在关联。这些发现为Z蛋白在动脉粥样硬化疾病发病机制中的作用提供了证据。
Summary Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients (102 male, 18 female; median age: 75 years) admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p < 0.05) lower in PAD patients [1,594 (89–3,635) ng/ml] compared to the healthy control group [1,728 (300–3,736) ng/ml].A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (<5th percentile of our control group: < 601 ng/ml) (OR: 5.72, 95%CI 3.07–10.66; p < 0.0001). After adjustment for age, gender and traditional cardiovascular risk factors the association was confirmed (OR: 5.83, 95%CI 2.83–12.01; p < 0.0001). Moreover, a significant association between low protein Z levels and clinical severity of the disease, evaluated through Fontaine’s stages, was reported after adjustment for age, gender, and traditional cardiovascular risk factors (general linear model, p for trend: 0.03). In conclusion, our data shows an association between low protein Z levels and the occurrence of PAD. These findings provide evidence for the role of protein Z in the pathogenesis of the atherosclerotic disease.
DOI：
10.1073/pnas.95.16.9250
发表时间：
1998-08-04
影响因子：
11.1
作者：
Han, X;Fiehler, R;Broze, GJ
通讯作者：
Broze, GJ