FLUORIDE INCORPORATION AND APATITE SOLUBILITY
FLUORIDE INCORPORATION AND APATITE SOLUBILITY
复制标题
DOI：
10.1159/000259853
复制
发表时间：
1973-01-01
期刊：
影响因子：
4.2
通讯作者：
DRIESSENS, FC
中科院分区：
文献类型：
--
作者：
DRIESSENS, FC
结合化学原理和固态化学原理，将离子化合物溶解度的经典理论推广到固溶体和偏离化学计量的情况。理论预测，在釉质磷灰石中引入外来离子可以以几种方式改变其溶解度积超过几个数量级。釉质组成的实验数据表明，F-离子的掺入将通过明显减少Na+和CO 32-掺入来稳定釉质晶体。另外的效果可能是，在釉质磷灰石晶体中的主要三元磷灰石的类型的变化，碳酸磷灰石到羟基磷灰石，是由相对少量的F-离子的掺入引起的。据估计，这些效应结合在一起使釉质磷灰石的溶解度积（以Koha计算）降低了5-10个数量级。本理论可用于筛选其他单一或组合的替代物，以了解其可能的防龋作用。动力学因素决定成功的预防离子掺入进行了讨论。
The classical theory on the solubility of ionic compounds has been extended to solid solutions and deviations from stoichiometry by combination of thermodynamical and solid state chemical principles. Theory predicts that the incorporation of foreign ions in enamel apatite can change its solubility product over several orders of magnitude in several ways. Experimental data on the composition of enamel indicate that the incorporation of F-ions will stabilize the enamel crystals by the apparent diminution of Na+and CO32-incorporation. The additional effect may be that a change in the type of the main ternary apatite in enamel apatite crystals, carbonatoapatite into hydroxyapatite, is induced by incorporation of a relatively small amount of F-ions. It is estimated that these effects in combination lower the solubility product of enamel apatite, calculated as Koha, by 5–10 orders of magnitude. The present theory can be used to screen other single or combined substitutions for their possible anticariogenic effect. Kinetic factors determining the success of prevention by ion incorporation are discussed.