Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats
Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats
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DOI：
10.1079/bjn20051436
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Nakano, Y
中科院分区：
文献类型：
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作者：
Sugimoto, K;Suzuki, J;Nakano, Y
蔗糖比淀粉更容易产生脂肪，过度摄入蔗糖会导致肥胖和肥胖。本研究的目的是检查桉树（蓝桉）叶提取物（ELE）对大鼠膳食蔗糖引起的肥胖的影响。此外，本研究还考察了ELE对肠道果糖吸收的影响。给大鼠喂食高蔗糖饮食（75%的卡路里基础），含或不含ELE（10 g/kg饮食），持续5周。ELE组大鼠体重低于对照组（342（sd37.9）v.392（sd26.0）g（n 7）; P < 0.05）。此外，ELE导致血浆（1.44（sd 0.448）v. 2.79（sd 0.677）mmol/l（n 7）; P < 0.05）和肝脏（19.1（sd 5.07）v. 44.1（sd 16.28）μ mol/g（n 7）; P < 0.05）中三酰甘油浓度降低。相反，ELE在喂食淀粉饮食的大鼠中没有显示出任何显著的影响。当大鼠口服ELE 10分钟前果糖给药，肠道果糖吸收，这是通过测量果糖给药后30分钟门静脉中的果糖浓度升高进行检查，显着抑制剂量依赖性的方式。此外，在喂食高果糖饮食的大鼠中，ELE显著降低了血浆和肝脏三酰甘油浓度。这些结果表明，ELE抑制肠道果糖吸收，可以抑制摄入大量蔗糖或果糖的大鼠的肥胖。
Sucrose is more lipogenic than starch, and the extreme ingestion of sucrose induces adiposity and obesity. The aim of this study was to examine the effect of the eucalyptus (Eucalyptus globulus) leaf extract (ELE) on adiposity due to dietary sucrose in rats. In addition, in this study, the effect of ELE on intestinal fructose absorption was also examined. Rats were fed a high-sucrose diet (75 % in calorie base) with or without ELE (10 g/kg diet) for 5 weeks. Body weight was lower in the rats receiving ELE than in the controls (342 (sd 37.9) v. 392 (sd 26.0) g (n 7); P < 0.05). Furthermore, ELE resulted in decreases in the triacylglycerol concentrations in the plasma (1.44 (sd 0.448) v. 2.79 (sd 0.677) mmol/l (n 7); P < 0.05) and liver (19.1 (sd 5.07) v. 44.1 (sd 16.28) mu mol/g (n 7); P < 0.05). In contrast, ELE did not show any significant effects in the rats fed a starch diet. When rats were orally given ELE 10 min before fructose administration, the intestinal fructose absorption, which was examined by measuring the elevated concentration of fructose in the portal vein at 30 min after the fructose administration, was significantly inhibited in a dose-dependent manner. Furthermore, in rats fed a high-fructose diet, the plasma and hepatic triacylglycerol concentrations were significantly decreased by ELE. These results indicate that ELE, which inhibits the intestinal fructose absorption, can suppress adiposity in rats that ingest large amounts of sucrose or fructose.