NITRIC-OXIDE FROM L-ARGININE STIMULATES THE SOLUBLE GUANYLATE-CYCLASE IN ADRENAL-GLANDS
NITRIC-OXIDE FROM L-ARGININE STIMULATES THE SOLUBLE GUANYLATE-CYCLASE IN ADRENAL-GLANDS
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DOI：
10.1016/s0006-291x(89)80037-3
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发表时间：
1989-12-15
影响因子：
3.1
通讯作者：
MONCADA, S
中科院分区：
文献类型：
--
作者：
PALACIOS, M;KNOWLES, RG;MONCADA, S
研究了l -精氨酸：NO合成酶在大鼠肾上腺和牛皮质髓质细胞质中生成一氧化氮（NO）及其对可溶性鸟苷酸环化酶的刺激作用。在l -精氨酸存在的情况下，可溶性鸟苷酸环化酶的刺激伴随着瓜氨酸和NO2-的形成。NO合成酶依赖于NADPH和Ca2+，并被几种l -精氨酸类似物抑制。这些结果表明，大鼠和牛肾上腺细胞质含有l -精氨酸：NO合成酶。
The formation of nitric oxide (NO) by an L-arginine:NO synthase and its stimulation of the soluble guanylate cyclase was studied in rat whole adrenal and bovine cortex and medulla cytosol. In the presence of L-arginine, the stimulation of soluble guanylate cyclase was accompanied by the formation of citrulline and NO2-, formed from NO. The NO synthease was NADPH- and Ca2+- dependent and was inhibited by several L-arginine analogues. These results indicate and rat and bovine adrenal cytosol contains an L-arginine:NO synthase.