A multimethod investigation of the behavioral activation system in bipolar disorder
A multimethod investigation of the behavioral activation system in bipolar disorder
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DOI：
10.1037/0021-843x.117.1.164
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发表时间：
2008-02-01
影响因子：
4.6
通讯作者：
Hetrick, William P.
中科院分区：
文献类型：
--
作者：
Hayden, Elizabeth P.;Bodkins, Misty;Hetrick, William P.
行为激活系统（BAS）活性失调与双相情感障碍（BPD）的发病机制有关。为了表征这种疾病的BAS活性和相关方面，作者比较了59名BPD患者和44名对照组的BAS活性的多项测量，包括标准化行为任务、自我报告和区域皮层活动的脑电图指数。假定的BAS活性水平因评估策略而异。当使用行为任务索引奖励敏感性时，心境良好的BPD患者比对照组参与者或处于情绪发作的患者显示出更高的BAS活动。经过设计诱发BAS活动的情绪诱导程序后，目前发作性患者的左前皮层活动相对大于正常或对照组的参与者。本文描述了这些发现对未来BPD脆弱性研究的意义。
Dysregulation in behavioral activation system (BAS) activity has been implicated in the pathogenesis of bipolar disorder (BPD). To characterize BAS activity and related facets in this disorder, the authors compared 59 participants with BPD to 44 controls on multiple measures of BAS activity, including a standardized behavioral task, self-reports, and electroencephalographic indexes of regional cortical activity. Levels of putative BAS activity differed depending on assessment strategy. When a behavioral task indexing reward sensitivity was used, euthymic BPD patients showed evidence of higher BAS activity than either control participants or patients who were in a mood episode. Following a mood induction procedure designed to elicit BAS activity, currently episodic patients showed relatively greater left anterior cortical activity than either euthymic or control participants. Implications of the findings for future research on BPD vulnerability are described.