Adiposity, asthma, and airway inflammation
Adiposity, asthma, and airway inflammation
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DOI：
10.1016/j.jaci.2006.10.029
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发表时间：
2007-03-01
影响因子：
14.2
通讯作者：
Hancox, Robert J.
中科院分区：
文献类型：
--
作者：
McLachlan, Christene R.;Poulton, Richie;Hancox, Robert J.
背景：一些研究发现肥胖与哮喘发病率增加有关。由于尚不清楚的原因，这种关联往往被报告在妇女中比在男子中更强。一个可能的解释是，这些研究使用体重指数来识别肥胖，这可能是一个不太可靠的测量身体脂肪的男性比女性。目的：我们试图探讨身体脂肪百分比之间的联系，测量通过生物电阻抗分析和哮喘，气流阻塞，气道炎症的男性和女性。方法：在大约1000名32岁的个体中进行基于人群的队列研究，测量呼吸问卷、肺功能测定、支气管扩张剂反应、呼出的一氧化氮水平和体脂百分比。在女性中，体脂百分比与哮喘之间存在显著相关性（P = 0.043），但在男性中则无相关性（P = 0.75）。气流阻塞与女性的体脂百分比相关（P = 0.046），但在男性中呈负相关（P = 0.010）。支气管扩张剂反应性也与男性较低的体脂相关（P = 0.004）。通过呼出的一氧化氮测量的气道炎症与女性（P = 0.17）或男性（P = 0.25）的体脂无关。结论：肥胖与女性哮喘和气流阻塞有关。这似乎不是由气道炎症介导的。在男性气流阻塞和支气管扩张剂的反应性与较低的体脂百分比。临床意义：在女性，但不是在男性，肥胖与哮喘和气流阻塞，但没有与气道炎症。
Background: Several studies have found obesity to be associated with an increased prevalence of asthma. For reasons that remain unclear, this association has often been reported to be stronger in women than in men. One possible explanation might be that these studies have used body mass index to identify adiposity, which might be a less reliable measure of body fat in men than in women.Objective: We sought to explore the association between body fat percentage measured by means of bioelectrical impedance analysis and asthma, airflow obstruction, and airway inflammation in men and women.Methods: Respiratory questionnaires, spirometry, bronchodilator response, exhaled nitric oxide level, and percentage of body fat were measured in a population-based cohort of approximately 1000 individuals at age 32 years.Results: There was a significant association between the percentage of body fat and asthma in women (P = .043) but not in men (P = .75). Airflow obstruction was associated with percentage of body fat in women (P = .046), but there was an inverse association in men (P = .010). Bronchodilator responsiveness was also associated with lower body fat in men (P = .004). Airway inflammation, measured by means of exhaled nitric oxide, was not associated with body fat in either women (P = .17) or men (P = .25).Conclusion: Adiposity is associated with asthma and airflow obstruction in women. This does not appear to be mediated by airway inflammation. In men airflow obstruction and bronchodilator responsiveness are associated with a lower percentage of body fat.Clinical implications: In women, but not in men, obesity is associated with asthma and airflow obstruction, but there was no association with airway inflammation.