Roles of Renal Proximal Tubule Transport in the Pathogenesis of Hypertension
Roles of Renal Proximal Tubule Transport in the Pathogenesis of Hypertension
复制标题
DOI：
10.2174/15734021113099990009
复制
发表时间：
2013-01-01
影响因子：
2.3
通讯作者：
Fujita, Toshiro
中科院分区：
文献类型：
--
作者：
Horita, Shoko;Seki, George;Fujita, Toshiro
高血压是心血管疾病的关键因素。许多器官和系统包括心脏、血管、肾脏、交感神经和内分泌系统参与血压的调节。特别是，肾脏在血压的调节中起着至关重要的作用，但也很容易受到高血压组织损伤的影响。例如，大多数慢性肾脏病（CKD）患者患有高血压，并且被发现具有比正常人群更高的死亡率。此外，高血压肾硬化症正在成为透析患者的第三大主要原因。本文就血管紧张素II和多巴胺对肾近曲小管转运的影响作一综述，这可能在血压调节中发挥重要作用。
Hypertension is a key factor of cardiovascular disease. Many organs and systems including heart, blood vessel, kidney, sympathetic nerve, and endocrine systems are involved in the regulation of blood pressure. In particular, the kidney plays an essential role in the regulation of blood pressure, but is also quite vulnerable to hypertensive tissue damage. For example, most chronic kidney disease (CKD) patients have hypertension and are revealed to have higher mortality than normal population. Furthermore, hypertensive renal sclerosis is emerging as the third main cause of dialysis patients. This mini review is to summarize the effects of angiotensin II and dopamine on renal proximal tubule transport, which may have important roles in the regulation of blood pressure.