ISOLATION IF A YAC CLONE COVERING A CLUSTER OF 9 S100 GENES ON HUMAN-CHROMOSOME-1Q21 - RATIONALE FOR A NEW NOMENCLATURE OF THE S100 CALCIUM-BINDING PROTEIN FAMILY
ISOLATION IF A YAC CLONE COVERING A CLUSTER OF 9 S100 GENES ON HUMAN-CHROMOSOME-1Q21 - RATIONALE FOR A NEW NOMENCLATURE OF THE S100 CALCIUM-BINDING PROTEIN FAMILY
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DOI：
10.1016/0888-7543(95)80005-7
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发表时间：
1995-02-10
期刊：
影响因子：
4.4
通讯作者：
HEIZMANN, CW
中科院分区：
文献类型：
--
作者：
SCHAFER, BW;WICKI, R;HEIZMANN, CW
S100蛋白是EF-手超家族的低分子量钙结合蛋白，似乎参与调节许多细胞过程，如细胞周期进展和分化。迄今为止，已从人类来源中描述了10多个S100蛋白家族成员，我们从人类染色体1 q21上分离到一个YAC克隆，在该克隆上可定位到9个不同的编码S100钙结合蛋白的基因。我们已经将编码S100 P的基因定位于人类染色体4p 16，从而完成了所有已知人类S100基因的染色体定位。S100基因在1 q21区域的聚集组织使我们能够为这些基因引入一个新的逻辑命名法，该命名法基于染色体上的物理排列，新的命名法应该促进和促进对该蛋白质家族的理解，并且易于扩展到其他物种。(C)出版社：Academic Press
S100 proteins are low-molecular-weight calcium-binding proteins of the EF-hand superfamily and appear to be involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. More than 10 members of the S100 protein family have been described from human sources so far, We have now isolated a YAC clone from human chromosome 1q21, on which 9 different genes coding for S100 calcium-binding proteins could be localized, Moreover, we have mapped the gene coding for S100P to human chromosome 4p16 and thereby completed the chromosomal assignments of all known human S100 genes. The clustered organization of S100 genes in the 1q21 region allows us to introduce a new logical nomenclature for these genes, which is based on the physical arrangement on the chromosome, The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species. (C) 1995 Academic Press, Inc.