NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS
NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS
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DOI：
10.1002/ana.410130302
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发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
TOURTELLOTTE, WW
中科院分区：
文献类型：
--
作者：
POSER, CM;PATY, DW;TOURTELLOTTE, WW
多发性硬化症（MS）的诊断和临床分型已经提出了几种方案[1]。最著名的是由Schumacher等人发表的31。该方案的标准是为了选择参与治疗试验的患者而建立的，并且只涉及可能被称为明确ms的患者，没有规定将支持性实验室数据纳入诊断标准。由于目前还没有发现诊断多发性硬化症的可靠的特异性实验室检测方法，因此多发性硬化症的诊断仍停留在临床阶段，尚需要临床诊断标准。然而，在过去十年中，一些实验室和临床程序已经发展起来，这些程序极大地帮助证明了可归因于病变的神经功能障碍，甚至病变本身。
Several schemes for the diagnosis and clinical classification of multiple sclerosis (MS) have been advanced [l}. The best known is that published by Schumacher et alC31. The criteria for this scheme were established in order to select patients for participation in therapeutic trials, and pertain only to what might be called definite MS. No provision was made for incorporating supportive laboratory data into the diagnostic criteria.As no reliable specific laboratory test for the diagnosis of MS has been discovered, the diagnosis remains a clinical one, and there is still a need for clinical diagnostic criteria. However, several laboratory and clinical procedures have been developed within the last decade which aid greatly in demonstrating neurological dysfunction attributable to lesions, and even the lesions themselves.