Autobiographical memory in mild cognitive impairment and Alzheimer's disease: A comparison between the Levine and Kopelman interview methodologies
Autobiographical memory in mild cognitive impairment and Alzheimer's disease: A comparison between the Levine and Kopelman interview methodologies
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DOI：
10.1002/hipo.22015
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发表时间：
2012-09-01
期刊：
影响因子：
3.5
通讯作者：
Chertkow, Howard
中科院分区：
文献类型：
--
作者：
Barnabe, Alexandra;Whitehead, Victor;Chertkow, Howard
以往的研究对自传体记忆的两个组成部分--个人语义记忆和情景记忆产生了不一致的结果。轻度认知障碍（MCI）和阿尔茨海默型痴呆（DAT）受试者的结果不同，关于逆行性遗忘的时间梯度的存在。这些结果具有重要的理论意义，多痕迹理论与标准的长期记忆（LTM）巩固模型。我们调查了这种差异是否源于评估自传体记忆的方法的差异。我们使用Kopelman的自传体记忆访谈（AMI）和Levine的自传体访谈（AI）研究了20名健康老年人对照组、20名MCI受试者和10名DAT受试者的记忆障碍模式。AMI和AI都进行了修改，以允许测试分数从一个单一的采访中得出，而不会使受试者疲劳。在AMI中，DAT受试者的自传体记忆、情节记忆和个人语义都显著受损，情节记忆显示出显著但温和的时间梯度，保留了童年记忆。使用AI测试，DAT受试者对情节细节（但不是个人语义）的回忆受损，同样具有温和的时间梯度。两种访谈方法之间的差异（较少的时期，在AMI;较少的记忆，每个时代的AI）被发现有显着影响的模式的结果;较少的时期，在AMI带来了时间梯度，和较少的记忆，每个时代（在AI）减少了它。这些数据显示的重要性，不同的测试技术细节，有利于一个与另一个LTM理论。这些数据与这两种理论都不完全相符。(c)2012 Wiley Periodicals，Inc.
Previous studies have produced inconsistent results concerning the two components of autobiographical memorypersonal semantic memory and episodic memory. Results in subjects with mild cognitive impairment (MCI) and dementia of Alzheimer's type (DAT) have varied concerning the existence of a temporal gradient in retrograde amnesia. These results have important theoretical implications regarding multiple trace theory versus standard consolidation models of long-term memory (LTM). We investigated whether this variability arises from differences in the methods used in assessing autobiographical memory. We examined patterns of memory impairment in 20 healthy elderly controls, 20 MCI subjects, and 10 DAT subjects using the Autobiographical Memory Interview (AMI) of Kopelman and the Autobiographical Interview (AI) of Levine. Both the AMI and AI were modified to allow for the test scores to be derived from a single interview without fatiguing the subjects. On the AMI, DAT subjects were significantly impaired on both components of autobiographical memoryepisodic memory and personal semanticswith episodic memory showing a significant though gentle temporal gradient sparing childhood memories. Using the AI test, subjects with DAT showed impaired recall of episodic details (but not personal semantics), again with a gentle temporal gradient. Differences between the two interview methods (fewer epochs in the AMI; fewer memories per epoch in the AI) were found to have a significant impact on the pattern of findings; fewer epochs in the AMI brought out the temporal gradient, and fewer memories per epoch (in the AI) diminished it. These data show the importance of technical details of the different tests in favouring one versus another LTM theory. The data are not purely compatible with either theory. (c) 2012 Wiley Periodicals, Inc.